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Genodermatoses affecting the nail
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
In the ectodermal dysplasia-skin fragility syndrome, a plakophilin-1 mutation leads to hair and teeth abnormalities. The nails become thickened. Histologically a widening of the intercellular spaces between the keratinocytes from the suprabasal to the granular layer is observed (Figure 6.7).109
Targeting Bone Metastases Signaling Pathway Using Moringa oleifera Seed Nutri-miRs: A Cross Kingdom Approach
Published in Nutrition and Cancer, 2022
Kinjal Bhadresha, Maulikkumar Patel, Jpan Brahmbhatt, Nayan Jain, Rakesh Rawal
We identified 94 miRNAs in M. oleifera seed and had the potential to regulate 47 significant human target genes with enormous biological and functional importance. Our identified miRNAs in the M. oleifera seed belong to at least nine different plant miRNA families: miRNA 156, 159, 166, 162, 172, 319, 395, 408, and 396 (Table 1), which are highly conserved in the kingdom Plantae. Between these, miR159, miR156 family, and miR164c were known as the most conserved miRNA families with suggestively higher GC content (69–71). These results indicated that the high GC-content is also an important characteristic of genes coding for transcriptional activators or repressors which have a noteworthy role in the regulation of gene expression under stress conditions. Furthermore, GC pairs are bound with three hydrogen bonds, these bonds are steadier and therefore increase the possibility of miRNA binding to the target gene (72). Furthermore, it was found that M. oleifera seed derived miR159, miR396a, miR1515, miR399a/d, miR5139, miR166b/h/I, miR165a, miR530, miR319, miR164a/c/d, miR395a/d/g, miR1511, miR156g/q, miR6478, miR319, miR7751, and miR394b regulate target genes that play a significant role in modulating various biological and molecular processes such as Biogenesis, Cellular process, Metabolic, Adhesion, Cellular Process, DNA repair, and mitotic recombination, splicing regulation and production of nitric oxide. Also, this gene was found to have a noteworthy role in numerous diseases like dystonia, torsion, autistic disorder, porphyria, acute hepatic, tyrosinemia, ectodermal dysplasia/skin fragility syndrome, acute myeloid leukemia, cleidocranial dysplasia, kaposi sarcoma, chronic myocardial ischemia, sclerosteosis, vitreoretinopathy, juvenile pilocytic astrocytoma, and fundus dystrophy.