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Principles of Clinical Diagnosis
Published in Susan Bayliss Mallory, Alanna Bree, Peggy Chern, Illustrated Manual of Pediatric Dermatology, 2005
Susan Bayliss Mallory, Alanna Bree, Peggy Chern
Differential diagnosisMastocytomaSpitz nevusBenign cephalic histiocytosisLangerhans cell histiocytosisTuberous xanthomaPapular xanthoma (Figure 17.24)Multicentric reticulohistiocytosis
Musculoskeletal (including trauma and soft tissues)
Published in Dave Maudgil, Anthony Watkinson, The Essential Guide to the New FRCR Part 2A and Radiology Boards, 2017
Dave Maudgil, Anthony Watkinson
Are the following statements regarding multicentric reticulohistiocytosis true or false? It is typified by osteopenia.It is associated with skin nodularity.It is due to infiltration by histiocytes.It is generally symmetrical.The metacarpophalangeal joints are generally the first involved.
Clinical and Radiological Diagnosis and Causes of Pulmonary Granulomas
Published in Philip T. Cagle, Timothy C. Allen, Mary Beth Beasley, Diagnostic Pulmonary Pathology, 2008
Multicentric reticulohistiocytosis (MRH) is characterized by infiltration of multinucleated giant cells and histiocytes into various tissues. The typical clinical picture consists of papular skin nodules and destructive arthritis. The disease usually occurs in the fourth decade and affects women three times more often than men, predominantly Caucasian women. About one-third of the patients may have an associated malignant lymphoma. MRH consists of multinucleated giant cells and histiocytes with eosinophilic PAS-positive cytoplasm. It can spontaneously resolve or it may progress to severe arthritis (11).
Multiple subcutaneous xanthogranuloma at juxta-articular sites with bone cystic changes resembling rheumatoid arthritis: A case report
Published in Modern Rheumatology, 2018
Shoichi Kaneshiro, Kenrin Shi, Kosuke Ebina, Masao Yukioka, Hideki Yoshikawa, Norikazu Murata
From the appearance of multiple subcutaneous nodules at juxta-articular sites, the differential diagnoses should include rheumatoid nodules, multicentric reticulohistiocytosis and pigmented villonodular synovitis. Rheumatoid nodules are often bony hard [7], but the nodules in our case were all soft to elastic soft. Multicentric reticulohistiocytosis, often resembling and misdiagnosed as RA, manifests multiple joint destruction including distal interphalangeal joints [8]. Although the nodules mostly occurred near the joints in our case, joint destruction was not recognized either radiographically or intra-operatively. The lesions of this case had some similarities to pigmented villonodular synovitis, but neither did they locate in synovial-lined tissues, nor have hemosiderin deposition [9]. Finally, these differential diagnoses were all denied by histopathological findings.