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Sjögren syndrome and mixed connective tissue disease
Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019
Livedoid vasculopathy presents as small punched-out painful ulcers on the lower legs, with peripheral retiform purpura, which heal with characteristic porcelain-white stellate scars (atrophie blanche) [48–52]. Sometimes, upper limbs may also be affected. Livedoid vasculopathic ulcers in a patient with MCTD can also occur as a part of coexistent antiphospholipid antibody syndrome.
Clinical presentations for chronic venous diseases
Published in Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland, Manual of Venous and Lymphatic Diseases, 2017
Ken Myers, Paul Hannah, Marcus Cremonese, Lourens Bester, Phil Bekhor, Attilio Cavezzi, Marianne de Maeseneer, Greg Goodman, David Jenkins, Herman Lee, Adrian Lim, David Mitchell, Nick Morrison, Andrew Nicolaides, Hugo Partsch, Tony Penington, Neil Piller, Stefania Roberts, Greg Seeley, Paul Thibault, Steve Yelland
Livedoid vasculopathy is a non-inflammatory thrombotic condition associated with abnormal coagulation factors.14 Histology shows segmental hyalinizing changes at the subintimal region of small dermal vessels with thrombotic occlusions. Strictly speaking, it is not a vasculitis as there are no neutrophilic inflammatory changes.
Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis
Published in Journal of Dermatological Treatment, 2022
Livedoid vasculopathy, also called livedo vasculitis and segmental hyalinizing vasculitis, is a type of chronic skin disorder. Livedoid vasculopathy is characterized by recurrent purpura or necrotic macules and painful ulcers on the lower extremities with summer exacerbations. These shallow ulcers may heal into atrophic porcelain satellite scars, termed atrophie blanche, and are often accompanied by peripheral telangiectasia and hyperpigmentation. The etiology and pathogenesis of livedoid vasculopathy still remain unknown. Livedoid vasculopathy is characterized histologically by intraluminal thrombosis, endothelial proliferation, and segmental hyalinization in dermal vessels. Therefore, livedoid vasculopathy is generally considered to be a thrombo-occlusive vasculopathy of cutaneous blood vessels, with occlusion of the cutaneous capillary microcirculation, leading to thrombosis, ischemia, and infarction (1).