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Differential Diagnosis
Published in Vineet Relhan, Vijay Kumar Garg, Sneha Ghunawat, Khushbu Mahajan, Comprehensive Textbook on Vitiligo, 2020
Hemant Kumar Kar, Gunjan Verma
Lichen striatus: Lichen striatus is an asymptomatic linear dermatosis that occurs mostly in children and has been reported to follow the lines of Blaschko. The primary lesions (small, flat, skin-colored to pink papules) can disappear spontaneously after several months or years, often leaving a linear macular hypopigmentation (postinflammatory).
Nail in dermatological diseases
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Piyush Kumar, Niharika Ranjan Lal
Both LN and lichen striatus are asymptomatic and self-healing with less potential for scarring or other permanent sequalae. Usually, no treatment is necessary. However, nail LS may have a protracted course of 6 months to 5 years, leading to patients seeking treatment. Treatment with topical tacrolimus ointment is reported to be successful in resolving nail changes.21
Inflammatory dermatoses affecting the nail
Published in Eckart Haneke, Histopathology of the NailOnychopathology, 2017
Lichen striatus is a rare self-limiting skin disease mainly affecting children and adolescents. Approximately 3% of the cases show nail involvement.139 It is characterized by an abrupt onset of linearly arranged scaly erythematous papules often involving an entire extremity. When the proximal nail fold is affected, there is usually also segmental nail involvement. This appears as longitudinal striation of a part of the nail, splitting, fraying, leukonychia, and partial or even total nail loss.140 There may also be isolated nail involvement.141,142 Usually, the disease clears spontaneously143 with the nail lesions lagging behind, but nail plate alterations may persist for a period of several years.144 Its etiology is not known, but many authors believe that it may be a manifestation of mosaicism, which is characterized by the presence of genetically abnormal keratinocyte clones. These are recognized by the immune system through a precipitating event and induce an inflammatory T-cell response mediated in the affected skin along the Blaschko lines.145,146 A viral trigger has also been suggested.137 Lichen striatus is assumed to be identical with adult blaschkitis.147–149
Postinflammatory hypopigmentation: a comprehensive review of treatments
Published in Journal of Dermatological Treatment, 2022
Pamela N. Madu, Nicole Syder, Nada Elbuluk
Phototherapy, particularly narrow band UVB (nbUVB), is a therapy used in the treatment of several conditions of hypopigmentation and depigmentation (28–30). With a peak wavelength of 311 nm, nbUVB promotes pigmentation by stimulation of melanocyte stimulating hormone (MSH), and increasing the proliferation, differentiation and migration of melanocytes (31). The 308 nm excimer laser has been used successfully in the treatment of vitiligo, nevus depigmentosus, idiopathic guttate hypomelanosis, and pityriasis alba (32–35). It has also demonstrated efficacy in the treatment of postinflammatory hypopigmentation (11). The excimer laser emits a wavelength of 308 nm UVB produced by xenon and chlorine gas and induces the migration, proliferation, and differentiation of melanocytes (36). A retrospective review of 12 patients with postinflammatory hypopigmentation secondary to lichen striatus and treated with excimer laser demonstrated complete response in 11 out of 12 patients (91.7%) after a median of 3 months and 17 treatment sessions (11). A study of 31 patients with hypopigmented scars or striae alba, assessed the efficacy of twice weekly nbUVB on these lesions compared to untreated lesions and normal skin. On visual and colorimetric assessment, mean pigment correction was 60–70% and 100% respectively after 9 treatments. However, after 6 months, pigment returned to baseline levels of hypopigmentation (5).
Bilateral hyperkeratosis of the nipples and areolae with linear nevus: a rare case report and review of the literature
Published in Postgraduate Medicine, 2018
Mei-fang Wang, Li Wang, Lin-feng Li
The hyperpigmented macules distributed in a linear fashion on the patient’s left forearm emerged in her childhood, enlarged gradually, and had no history of itching, pain, or a self-healing tendency. In accordance with her medical history, the diagnoses of lichen striatus, lichen planus linearis, and psoriasis zosteriformis could be excluded. In light of these lesions’ distribution in a Blaschko-linear pattern and lack of symptoms or hypertrichosis since she was young, the diagnosis was considered to be linear nevus, also known as epidermal nevus. These epidermal nevi occur as single or multiple lesions, present as yellowish-brown, velvety, granular or warty plaques, and typically have a linear or whorled configuration following the lines of Blaschko. The nevi are usually seen at birth or develop in early childhood and evolve until puberty [17]. The patient could not describe the chronological sequence of two lesions, but she was sure that both appeared at an early age.
A comprehensive review of platelet-rich plasma for the treatment of dermatologic disorders
Published in Journal of Dermatological Treatment, 2023
Jessica N. Pixley, Madison K. Cook, Rohan Singh, Jorge Larrondo, Amy J. McMichael
Inflammatory nail disorders are a group of conditions that may be isolated to the nail or concomitant with systemic disease. These disorders include lichen planus, lichen striatus, and idiopathic trachyonychia. Treatment of nail lichen planus has been attempted with topical tacrolimus, intralesional or systemic steroids, azathioprine, and etretinate, although efficacy is variable (39). Nail lichen striatus and idiopathic trachyonychia are both conditions that may spontaneously resolve. Persistent lichen striatus has been treated with intralesional triamcinolone, while persistent trachyonychia may be treated with topical or intramatricial corticosteroids, tazarotene gel, or topical 5-fluorouracil cream (40,41).