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Papulosquamous disorders
Published in Aimilios Lallas, Enzo Errichetti, Dimitrios Ioannides, Dermoscopy in General Dermatology, 2018
Aimilios Lallas, Enzo Errichetti
This clinical subtype of psoriasis selectively involves folds (i.e., inguinal, gluteal, submammary, axillae, and groin) and the genital regions. Inverse psoriasis frequently occurs in patients who are obese.
Inverse psoriasis and genital disease
Published in M. Alan Menter, Caitriona Ryan, Psoriasis, 2017
Inverse psoriasis refers to a variant of the disease that affects flexural and intertriginous skin and can have a profound impact on quality of life. Reports show that up to 36% of psoriasis patients have flexural disease and that 2%–7% of psoriasis patients present with this primary pattern of lesions in isolation.1–4 Due to the infrequency of this variant, it is often misdiagnosed and mistreated.
Erythema
Published in Giuseppe Micali, Pompeo Donofrio, Maria Rita Nasca, Stefano Veraldi, Vulval Dermatologic Diagnosis, 2015
Giuseppe Micali, Maria Rita Nasca, Stefano Veraldi
Definition: Psoriasis is a chronic and/or relapsing erythemato-squamous inflammatory skin disorder. Inverse psoriasis is a clinical variant that is characterized by a predominant involvement of the great folds (including the genitocrural area).
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis
Published in Expert Opinion on Drug Delivery, 2021
Based on clinical manifestations, psoriasis can be categorized into five types, namely, psoriasis vulgaris, inverse, guttate, erythrodermic, and pustular psoriasis. Usually, a patient is affected by only one particular type at a time. The treatment regime depends on the criticality of the disease and varies among patients [5]. Out of all the different types, psoriasis vulgaris occurs in majority of the cases. In this type, reddish round or oval plaques are found in the joint region like knees and elbows [6]. Inverse psoriasis is also known as flexural psoriasis and occurs in folded regions of the body like armpits, genitals, breasts, etc. Nearly 18% of psoriatic patients suffer from this type [7]. Guttate psoriasis generally starts from childhood and occurs due to bacterial infection. Here, tiny droplet-like sores appear on arms, scalp, and legs [8]. Erythrodermic psoriasis is an inflammatory form of this disease that forms scales and redness to most of the body parts. Some patients experience tachycardia, shading of scales and sudden change in body temperature [9]. The last type, pustular psoriasis, is usually seen as pustules on the skin of feet or hands. Very few psoriatic patients are affected by this type [10]. Psoriatic patients also suffer from other morbidities. They have high risks of depression and metabolic complications. Additionally, it has been observed that around 30% of psoriatic patients suffer from psoriatic arthritis [11,12].
Treatments for inverse psoriasis: a systematic review
Published in Journal of Dermatological Treatment, 2020
Kelly A. Reynolds, Deeti J. Pithadia, Erica B. Lee, Jashin J. Wu
Inverse psoriasis, also known as intertriginous psoriasis, is characterized by well-demarcated, erythematous lesions occurring in body folds, specifically in the axillary, anogenital, and inframammary areas. This is in contrast to the most common variant plaque psoriasis, which generally affects extensor surfaces such as the knees, elbows, and sacrum, as well as the scalp (1). In most cases, inverse psoriasis is accompanied by plaque psoriasis lesions elsewhere on the body, although, rarely, intertriginous regions may be exclusively affected (1,2). The prevalence of inverse psoriasis is difficult to approximate due to a lack of diagnostic criteria regarding involvement of specific body areas to warrant the diagnosis. One textbook states that the prevalence of inverse psoriasis in patients with plaque psoriasis is between 2 and 6% (3), while another study reports that 44% of patients with plaque psoriasis suffer from perianal involvement (4).
Psoriatic arthritis for dermatologists
Published in Journal of Dermatological Treatment, 2020
Alice Gottlieb, Joseph F. Merola
Although psoriasis can occur in a variety of locations on the body, specific manifestations are clinical predictors of PsA (68). Several studies have found an increased risk of PsA has correlations with psoriatic scalp lesions, intertriginous/inverse psoriasis, and nail dystrophy (68–71). The hazard ratios for PsA in patients with scalp, intergluteal/perianal, and nail psoriasis are 3.89, 2.35, and 2.93, respectively (68), and in mild psoriasis, 83% of patients with scalp and nail psoriasis, 40% of patients with intergluteal/perianal lesions, and 37% of patients with isolated scalp psoriasis met CASPAR criteria for PsA (69). Similarly, the incidences of scalp, intergluteal, and nail psoriasis were higher in patients with PsA (100, 83, and 64%, respectively) than in patients with psoriasis alone (67, 25, and 40%, respectively) (70). Recognition of inverse psoriasis is an important clue for informing a diagnosis of PsA that is commonly missed during physical examination. Inverse psoriasis has typically been considered uncommon but contemporary findings report a prevalence of 21–30% for inverse psoriasis in patients with psoriasis (72).