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Guttate hypomelanosis and progressive hypomelanosis of the trunk (progressive macular hypomelanosis)
Published in Electra Nicolaidou, Clio Dessinioti, Andreas D. Katsambas, Hypopigmentation, 2019
Alexander Katoulis, Efthymia Soura
It is uncertain whether genetic factors play a role in the pathogenesis of IGH, although a correlation with specific HLAs (human leukocytic antigens) has been established.10,11 One the other hand, continuous microtrauma may play an important role in the appearance of IGH.4 Defective local melaninogenesis has also been included in the possible causes of IGH.12–15
Idiopathic guttate hypomelanosis: Presentation and Management
Published in Journal of Cosmetic and Laser Therapy, 2021
Jeta Buch, Anant Patil, George Kroumpouzos, Martin Kassir, Hassan Galadari, Michael H. Gold, Mitchel P. Goldman, Stephan Grabbe, Mohamad Goldust
IGH typically presents in early adult life or maturity. IGH is characterized by multiple, discrete, asymptomatic, well-defined, round or oval, depigmented macules of approximately 0.5–6 mm in diameter. Usually, these lesions do not enlarge; however, Shin and colleagues reported a gradual increase in the size of these lesions in 16% of their patients (6). In young individuals, the lesions are scanty (less than five) and not larger than 2 mm. However, in mature persons (i.e., >50 years old), lesions are numerous (usually >30 or 50) and larger (3–5 mm) (7).
Comparative study of ablative fractional photothermolysis versus topical retinoid cream in the treatment of idiopathic guttate hypomelanosis
Published in Journal of Cosmetic and Laser Therapy, 2018
Won Seon Koh, Jeong Eun Kim, Young Suck Ro, Joo Yeon Ko
Idiopathic guttate hypomelanosis (IGH) is a common acquired leukoderma in middle-aged to elderly patients and is characterized by asymptomatic, round to oval, hypopigmented macules on sun-exposed areas. Although the exact cause of IGH is unknown, it is generally accepted that IGH is a disorder associated with photoaging (1). Although IGH does not cause any functional disorders, patients with IGH may seek medical or procedural treatments owing to its cosmetic appearance.