China
Africa
Explore chapters and articles related to this topic
Epilepsy and exanthema
Published in Dinesh Kumar Jain, Homeopathy, 2022
Dengue or break bone fever is a specific fever lasting not more than 7 days and mainly confined to tropical climates … Often within 1 to 2 days the skin over the face, neck and chest becomes flushed and reddened (primary rash) … by the 3rd or 4th day, the temperature falls to 100°F or lower, with sweating and perhaps diarrhoea. The patient temporarily feels better, but after a few hours to 3 days the temperature again rises … the pain returns and a secondary rash appears which … lasts a few hours to 3 days. Desquamation and itching follow.
Squamous Cell Carcinoma
Published in Debjani Sahni, Adam Lerner, Bilal Fawaz, Advanced Skin Cancer, 2022
Radiation therapy (RT) is an alternative treatment option for non-surgical candidates. RT offers the advantage of treating subclinical extension through a field margin, and it can be used either as primary treatment or in the adjuvant setting.2 It is typically reserved for older patients (>60 years old) due to concern for potential long-term sequelae (most importantly, radiation-induced malignancies). The recurrence rate is less than 7.9%.8 Complications of radiation are divided into acute and late. Acute complications are usually encountered during or shortly after treatment and include erythema, moist desquamation, and fatigue. Late complications are encountered months to years after treatment and include skin dyspigmentation, hair loss, telangiectasias, and skin atrophy. Absolute contraindications to the use of radiation include previously radiated tumors that received the maximum radiation dose, as well as patients with radiation hypersensitivity syndromes (e.g., xeroderma pigmentosum). Relative contraindications include young age (<40 years old), lower limb (due to poor wound healing), connective tissue disease (such as scleroderma or lupus), peripheral vascular disease, and patients who are less able to cooperate (e.g., movement disorders or dementia).11
Thermoluminescence Dosimetry
Published in Arash Darafsheh, Radiation Therapy Dosimetry: A Practical Handbook, 2021
In radiotherapy, skin dose can mean the dose to the basal cell layer around 0.07 mm deep. While TLDs are typically too thick to give a meaningful result for such a shallow depth, TLD extrapolation or black TLDs can be used [48, 57]. This is relevant for skin toxicity such as desquamation.
Long-term effects of total skin electron beam therapy for mycosis fungoides on hair and nail loss and regrowth
Published in Journal of Dermatological Treatment, 2022
Debra L. Breneman, Alyssa Breneman, Elaine Ballman, John C. Breneman
As part of a National Cancer Institute protocol, two patients received concomitant chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), administered according to the CHOP regimen described by McKelvey et al. (9). One of these patients received four cycles of CHOP and the other patient received three. Chemotherapy was discontinued prematurely in both of these patients due to cutaneous toxicity, including desquamation and a pustular reaction. One patient, who did not receive concomitant chemotherapy, began treatment with methotrexate for disease relapse 15 months after TSEBT was completed, and was therefore not included in the 18-month data analysis. One patient who received chemotherapy concomitant with TSEBT was treated with PUVA 6 months after completion of TSEBT and is included in the complete data analysis. All other patients remained in complete continuous remission following completion of TSEBT for a follow-up of 18 months. Thirteen of the fifteen patients were treated with daily topical mechlorethamine for 1 year following completion of TSEBT.
Topical application of Jatyadi Ghrita and Jatyadi Taila accelerates wound healing in Sprague-Dawley rats: a study in gamma-radiation-induced skin wound model
Published in International Journal of Radiation Biology, 2021
Vanita Gupta, Anuradha Tyagi, Aseem Bhatnagar, Sukhvir Singh, Sudesh N. Gaidhani, Narayan Srikanth
Further, increased CFU counts observed in radiation wounds throughout the study indicated that radiation has compromised the normal microbial flora with proliferation of microbes in moist wounds (Figure 4). Loss of skin integrity due to wounding exposes the underneath cutaneous tissue which in turn provides a moist, warm, and nutritious environment supportive to microbial colonization and proliferation. There is high propensity for infection with moist desquamation as it leads to loss of epidermal layers. Superinfection with Staphylococcal further intensifies the inflammatory process and obstruct repair of epidermal barrier (Hill et al. 2004). In this study, we have also found abundance of cocci species in our wound model (data not shown). Application of formulations has reduced the microbial load in wounds on all the time intervals observed with normalization to near control by day 42 suggested the antimicrobial properties of various herbal components present in JG and JT. Presence of herbal components in JG and JT viz. Azadirachta indica, Curcuma longa, Berberis aristata, Terminalia chebula, Symplocos racemosa synergistically rendered antimicrobial activity (Biswas et al. 2002; Singh et al. 2002; Devmurari 2010; Mazumder et al. 2011). The reduction in CFUs can be directly correlated with reduction in wound area and SDS.
Erythema multiforme after treatment with sorafenib
Published in Baylor University Medical Center Proceedings, 2021
Aaminah Faheem Azhar, Rachael Camille Saporito, Jordan Jamerson
A 7-year-old white boy presented because of a widespread pruritic, erythematous rash across his face, trunk, and extremities for 5 days. He denied any symptoms of recent illness. He started the chemotherapy medication sorafenib 9 days before developing the rash. He was not on other medications and had no known drug allergies. His past medical history included a mediastinal desmoid tumor previously treated with neoadjuvant chemotherapy followed by surgical resection with multiple positive margins. On examination, he appeared well, and his vital signs were within normal limits. There were edematous, erythematous papules and plaques on his face, chest, trunk, glans and shaft of penis, scrotum, and bilateral upper and lower extremities, including both dorsal and volar surfaces of the hands and feet (Figure 1). A number of the papules had an atypical targetoid appearance with dusky centers. He also had two aphthous ulcers along the hard palate. A complete blood count was normal. A biopsy was offered and declined. The patient was clinically diagnosed with EM given the timing and appearance of the rash and mucosal involvement. He was advised to discontinue sorafenib and prescribed prednisolone 0.5 mg/kg/day with a 3-week taper. The rash slowly faded without desquamation and resolved within a few weeks.