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Desmoplastic trichoepithelioma
Published in Longo Caterina, Diagnosing the Less Common Skin Tumors, 2019
Desmoplastic trichoepithelioma (DTE) is a variant of trichoepithelioma with specific clinicopathologic features. It occurs almost exclusively on the face of young adult women, in particular on the forehead and malar regions. Desmoplastic trichoepithelioma generally appears as a solitary, hard, small plaque of 5 mm in diameter, with raised borders and a depressed center, which gives an annular appearance. Occasionally, lesions are multiple.1 On histopathologic examination, DTE appears as a dermal well-circumscribed lesion with a central depression. The tumor is made of irregular cords and small nests of basaloid cells and keratinous cysts, which are frequently calcified. Atypical mitoses and cytologic atypia are absent. An abundant, dense and hypocellular desmoplastic stroma surrounds these epithelial structures.2
Efficacy and safety of lasers in treating syringomas: a review of the literature
Published in Journal of Dermatological Treatment, 2022
Syringomas are benign adnexal neoplasms caused by an overgrowth of cells from sweat glands of eccrine origin (1). These lesions are small, multiple, asymptomatic, smooth, firm, skin-to-yellow-colored papules that frequently develop in clusters in a bilateral, symmetrical distribution (2). Based on clinical features and associations, Friedman and Butler classified syringomas as a localized form, a familial form, a type linked with Down syndrome, and a generalized form with numerous and eruptive syringomas (3). Syringomas are predominantly present around the periorbital region, especially the lower eyelids and are less prevalent on the forehead, scalp, cheeks, abdomen, extremities, axilla, buttocks, and genitalia (4). Although the appearance of syringomas is most frequent in the third and fourth decades of life, studies have also shown that they can occur in any age group before or after puberty (5). Syringomas are more common in women (6) and patients with Down syndrome (7). The female preponderance may be explained by the influence of hormones. The racial predilection for syringoma is not widely reported. However, eruptive syringomas are thought to be more common in African Americans and Asians (8). The mechanism for the formation of the lesions in syringoma is largely unknown. Clinical presentation of eruptive syringomas can be confused with acne vulgaris, milia, sebaceous hyperplasia, lichen planus, urticaria pigmentosa, hidrocystoma, and eruptive xanthoma on the face. Further, syringomas on the face may resemble sclerosing basal cell carcinoma and desmoplastic trichoepithelioma, while lesions on the eyelids may resemble xanthelasma. Syringomas have specific histopathological features, hence histological investigation can be used to provide a definitive diagnosis (2).
Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma
Published in Orbit, 2018
Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Clinically and histopathologically, MAC is most commonly misdiagnosed as basal cell carcinoma or desmoplastic trichoepithelioma. Squamous cell carcinoma is the diagnosis when the lesion is in periocular region.4 MAC is usually solitary and occurs as a flesh or pale/yellow nodule or deep-seated plaque. It is firm, often with diffuse, ill-defined margins and overlying telangiectasia. The overlying epidermis may appear normal, atrophic, or scaly. Ulceration is unusual.4