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Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
These patterns varied from time to time within patients depending on degree of exposure, treatment and chronicity. Continued exposure often culminated in the picture of chronic actinic dermatitis. Involved sites other than the face were the hands (74%), particularly the backs of the hands and finger webs (probably because of aftershave trickling from the palms between the fingers during application and from light-exposure), the arms (42%), the trunk (31%), the legs (26%), and the axillae (20%), due to deodorant usage (31).
Beclomethasone Dipropionate
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A 57-year-old atopic man had a 25-year history of hand and foot dermatitis, recently spreading to the backs of the hands and the face in an exposed-site distribution. His asthma was treated with a beclomethasone dipropionate inhaler. He had used a variety of topical corticosteroids. Patch testing with the European baseline series was positive to tixocortol pivalate. Further testing to 18 individual corticosteroids revealed positive reactions to beclomethasone dipropionate 2% alcohol and 3 other glucocorticoids. Photopatch testing was negative but phototesting to UV light was positive at 330, 360 and 400 nm. In view of his multiple contact sensitivities and photosensitivities, a diagnosis of chronic actinic dermatitis was made (4).
Chronic Actinic Dermatitis
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Chronic actinic dermatitis is an uncommon, sometimes disabling eczematous photosensitivity eruption affecting predominantly elderly men. It arises spontaneously or in association with other pre-existing photosensitive or eczematous disorders and is induced by ultraviolet (UV) and occasionally also visible irradiation. Sun-exposed and often covered skin is affected by eczematous or on occasion pseudolymphomatous changes. Concomitant contact or, less commonly, photocontact sensitivity to airborne or other allergens may be present. The disease generally persists throughout the year, although exacerbations tend to occur during summer. Most patients retain the disorder indefinitely in the absence of treatment, although remission may rarely occur.
The emerging role of dupilumab in dermatological indications
Published in Expert Opinion on Biological Therapy, 2021
Maddalena Napolitano, Adriana Di Guida, Mariateresa Nocerino, Gabriella Fabbrocini, Cataldo Patruno
PDare a broad group of skin conditions probably associated with a Th2-mediated inflammation [125]. In literature, 2 cases of chronic actinic dermatitis and 1 of actinic prurigo have been treated with dupilumab [126–128]. PEO is a rare disease characterized by higher levels of IL-4, IL-13, and IL-22 in serum [129]. Three patients successfully treated with dupilumab have been reported [130,131]. EAE is another rare chronic skin disease for which there is no gold standard therapy [132]. In literature, there are 2 case reports of therapeutic success with dupilumab [133,134]. Finally, a single case of EBP successfully treated with dupilumab has been described [135].
Off-label studies on tofacitinib in dermatology: a review
Published in Journal of Dermatological Treatment, 2021
Kyle Tegtmeyer, Jeffrey Zhao, Nolan J. Maloney, Giancarlo Atassi, Molly Beestrum, Peter A. Lio
There are numerous dermatologic conditions for which case reports on treatment with tofacitinib are available, including chronic actinic dermatitis, dermatomyositis, pyoderma gangrenosum, and several others. In these case reports, tofacitinib is used as either a monotherapy, or in conjunction with other medications. The results of these case series and case reports are detailed in Table 3.
Tofacitinib in the treatment of refractory eczemas – a case series
Published in Journal of Dermatological Treatment, 2022
Prasanna Duraisamy, Soumya Jagadeesan, Jacob Thomas
The clinical spectrum of disease included contact dermatitis in six patients, atopic dermatitis in three, chronic actinic dermatitis in two and prurigo nodularis in one. Histopathologic examination showed spongiotic dermatitis in all patients with additional psoriasiform dermatitis pattern in two patients.