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Other infiltrative conditions
Published in Aimilios Lallas, Enzo Errichetti, Dimitrios Ioannides, Dermoscopy in General Dermatology, 2018
Enzo Errichetti, Aimilios Lallas
Moving to NLCHs, they are often divided into forms with exclusive/predominant skin involvement (juvenile and adult-onset xanthogranuloma, papular xanthoma, generalized eruptive histiocytosis, benign cephalic histiocytosis, solitary and diffuse cutaneous reticulohistiocytosis, and progressive nodular histiocytosis) and forms with common systemic involvement (xanthoma disseminatum, Erdheim–Chester disease, multicentric reticulohistiocytosis, necrobiotic xanthogranuloma, and Rosai–Dorfman disease).2 From a dermatological point of view, all such conditions usually present with red-orangish, red-brown, or yellowish papules/nodules, whose localization varies according to the subtype, although the head, trunk, and skin folds are generally the most commonly involved sites.2 Interestingly, forms with exclusive/predominant skin involvement tend to have discrete (nonconfluent) lesions, while forms with extracutaneous involvement often display lesions that form groups or merge into plaques.2
Principles of Clinical Diagnosis
Published in Susan Bayliss Mallory, Alanna Bree, Peggy Chern, Illustrated Manual of Pediatric Dermatology, 2005
Susan Bayliss Mallory, Alanna Bree, Peggy Chern
Benign cephalic histiocytosis: 2-5-mm yellow-red papules on the face and neck in a child <1 year of age (non-Langerhans cell histiocytosis) Clonal neoplastic disorder of Langerhans cells (monocyte/macrophage which contains Birbeck granules; expresses CD1 glycoprotein)
Progressive mucinous histiocytosis treated successfully with thalidomide: a rare case report
Published in Journal of Dermatological Treatment, 2023
Reem Diab, Mohammad Shahidi Dadras, Azadeh Rakhshan, Ali Kaddah, Fahimeh Abdollahimajd
Histiocytosis is divided into two sub-groups: Langerhans and non-Langerhans cell histiocytosis, distinguished by the immunophenotype of the affected cells (3). Langerhans cell histiocytosis (LCH) includes Letterer–Siwe disease, Hand-Schüller-Christian disease, eosinophilic granuloma, congenital self-healing, and adult LCH, staining positively for CD1a, S100 protein, and CD207 (langerin), and negatively for CD68, CD163, and factor XIIIa (3). Non-Langerhans cell histiocytosis (non-LCH) is divided into three subgroups: primarily cutaneous, cutaneous with systematic involvement, and primarily extra-cutaneous in addition to skin involvement (4). Non-LCH includes juvenile xanthogranuloma, xanthoma disseminatum, benign cephalic histiocytosis, progressive nodular histiocytosis, spindle cell xanthogranuloma, and generalized eruptive histiocytosis, which are of dendritic origin; HPMH was later added to this group (5).