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Scutellaria Species and Cancer Research
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Samantha H. Sherman, Lani Irvin, Prahlad Parajuli, Nirmal Joshee
Scutellaria barbata is native to China and is known as Ban-Zhi-Lian in traditional Chinese medicine (TCM), where it is used for its diuretic, anti-cancer and anti-inflammatory activities (Yu et al., 2004). According to the Taiwan National Health Insurance Research Database, S. barbata is one of the most commonly used TCM-based herbs for the treatment of breast cancer (Yeh et al., 2014). The prominent phytochemicals identified in S. barbata include various flavonoids, alkaloids, essential oils, terpenoids and polysaccharides. Of these, flavonoids rank as the most important component of S. barbata, as these compounds contain antioxidant, anti-cancer and anti-inflammatory functions (Gao et al., 2019). Studies suggest that flavonoids such as scutellarin and carthamidin serve as the main anti-cancer effector component of S. barbata aqueous extract, BZL101 (FDA IDN# 59521), which showed promising inhibitory activity against metastatic breast cancer in a phase I/II clinical trials (Rugo et al., 2007; Fong et al., 2008; Chen et al., 2012). The overall BZL101 efficacy is determined by the combined activity of its components acting synergistically toward selective cytotoxicity against cancer cells (Chen et al., 2012).
Green Metal-Based Nanoparticles Synthesized Using Medicinal Plants and Plant Phytochemicals against Multidrug-Resistant Staphylococcus aureus
Published in Richard L. K. Glover, Daniel Nyanganyura, Rofhiwa Bridget Mulaudzi, Maluta Steven Mufamadi, Green Synthesis in Nanomedicine and Human Health, 2021
Abeer Ahmed Qaed Ahmed, Lin Xiao, Tracey Jill Morton McKay, Guang Yang
The bioreduction involved in reducing the ions of zinc oxide to form ZnO-NPs were confirmed with the use of phytochemicals such as terpenoids, polysaccharides, alkaloids, phosphorous compounds, secondary sulfonamides, polyphenolic compounds, amino acids, vitamins, amino acids, diketone and vinyl (Agarwal et al., 2017). Steroids, diterpenoids, polysaccharides, flavonoids and alkaloids from Scutellaria barbata were found to be involved in AuNPs bioreduction (Wang et al., 2009). Ketones were reported to play an important role in the synthesis of AgNPs using plant extracts (Yilmaz et al., 2011). Punica granutum fruit peel extracts were subjected to FTIR analysis to show the presence of phenolic hydroxyls (O─H band) as well as an aromatic ring that acted as a functional group in capping AuNPs (Ganeshkumar et al., 2013). The amine groups from Hibiscus rosa sinensis leaf extract bonded with AuNPs. Moreover, carboxylate ion groups from the same plant extract (Hibiscus rosa sinensis) were found to bind with AuNPs and AgNPs (Philip, 2010). AuNPs were functionalized with stabilizing functional groups from Stevia rebaudiana extracts such as biomolecules with primary carbonyl group or amine group (─NH2) (Sadeghi et al., 2015).
Integrative hyperthermia treatments for different types of cancer
Published in Clifford L. K. Pang, Kaiman Lee, Hyperthermia in Oncology, 2015
Clifford L. K. Pang, Kaiman Lee
Proven prescription 3: Soldago decurrens Lour 30 g, Scutellaria barbata 30 g, Scrophularia ningpoensis 30 g, Paris polyphylla Sm. 30 g, Radix sophorae Tonkinensis 15 g, Fructus arctii 15 g, Cremastra appendiculata 15 g, Nidus vespae 15 g, Prunella vulgaris 12 g, Bombyx batryticatus 12 g, Gekko 9 g, Puffball 6 g, Platycodon grandiflorum 6 g, and Licorice roots 6 g. Decoct drugs into steam, and have the patients inhale the steam through both nose and mouth. Efficacy: clears throat heat and removes dampness. It is applicable to patients with the syndrome of accumulated dampness toxicity in the initial-medium term of oral cancer.
Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Lei Wang, Jianwei Xu, Ye Yan, Han Liu, Thiruventhan Karunakaran, Feng Li
Scutellaria barbata is one of the important species of the Scutellaria genus. It is commonly called “Ban Zhi Lian” in Chinese. Historically, this species was used widespread as food or medicines for the treatment of various diseases and it was extensively researched for its therapeutic properties. In the traditional Chinese system of medicine, this plant is widely used to treat various human ailments due to its high medicinal value. Hence, its name “the miracle root for the preservation of life”. Scutellaria barbata has a potent antitumor activity in breast cancer [17], colorectal cancer [18], hepatocarcinoma [19], skin cancer [20], lung cancer [21], and ovarian cancer [22]. Moreover, Lee et al., (2017) [23] reported that the active fractions of Scutellaria barbata have anti-inflammatory activity in BV-2 cells. The present research study was mainly focused on the synthesis of gold nanoparticles from the Scutellaria barbata by green route method and evaluation of its anticancer activity against pancreatic cancer cell lines (PANC-1).