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Natural Product Compounds from Plants in Neurodegenerative Diseases
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Priya Darshani, Md TanjimAlam, Prem P. Tripathi, V.S. Pragadheesh
Alkaloids isolated from different plants such as berberine, stylopine, epiberberine, pseudodehydrocorydaline, pseudocopsitine, pseudoberberine, 19,20-dihydrotabernamine and 19,20-dihydroervahanine A exhibited strong AChE inhibitory activity. Bacopa monnieri (L.) Wettst., Convolvulus pluricaulis Choisy, Acorus calamus L. and Clitoria ternatea L., which are well known for their memory-enhancing properties, have shown significant inhibition of AChE. Salvianolic acid A, a polyphenol from S. miltiorrhiza and rosmarinic acid from Salvia species, were shown to inhibit Aβ aggregation. Flavonoids such as myricetin, kaempferol, quercetin, morin, apigenin, kuwanon C, kuwanon A, morusin, and norartocarpetin have shown potent β-secretase inhibition. Diarylheptanoid, a derivative root extract of Myrica cerifera L., (-)-epicatechin-3-gallate from C. sinensis, myricetin and (+)-aR, 11S-myricanol have demonstrated tau protein inhibition activity (Malik, 2017).
The role of nutrition on Parkinson’s disease: a systematic review
Published in Nutritional Neuroscience, 2023
Vittorio Emanuele Bianchi, Laura Rizzi, Fahad Somaa
In animal models, it was demonstrated that many foods rich in polyphenols exerted a neuroprotective effect. The citrus flavanone naringenin significantly increased the content of tyrosine hydroxylase (TH) in neurons, reducing the loss of DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain [116]. The naringin (glycoside of naringenin) [117], flavanone glycoside found in citrus fruits − hesperidin [118], and myricitrin, derived from the root bark of Myrica cerifera, stimulated the activation of mTORC1 and TH activity [97]. Epigallocatechin-3-gallate (EGCG), [119] a major flavone in tea, curcumin had a potent antiparkinsonism effect in mice in combination with curcumin and niacin [120]. This protective effect has been suggested to be attributed to tea polyphenols’ antioxidant, anti-inflammatory, and anti-excitotoxic activity [121].