China
Africa
Explore chapters and articles related to this topic
The Orient
Published in Michael J. O’Dowd, The History of Medications for Women, 2020
The mulberry, Morus alba, was dispensed with the peach (Prunus persica) in the treatment of disease by the Queen of the West, Hsi-Wang-Mu. The leaves (sang ye), branches (sang zhi), root bark (sang bai pi), and the fruits (sang shen) are currently used in Western herbal medicine and are thought to have antibacterial properties. Mulberry leaves are the preferred food of the silkworm, Bombyx mori. Indian mulberry, Morinda citrifolia, and others of this genus, are astringents and purgatives. In TCM morinda root, Morinda officinalis, Bajitian in Chinese, is prescribed for infertility, impotence, menstrual disorders and seminal emission (PPRC, 1992).
Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways
Published in Pharmaceutical Biology, 2018
Kiran Kumar Soni, Li Tao Zhang, Bo Ram Choi, Keshab Kumar Karna, Jae Hyung You, Yu Seob Shin, Sung Won Lee, Chul Young Kim, Chen Zhao, Han-Jung Chae, Hye Kyung Kim, Jong Kwan Park
MOTILIPERM was prepared as a mixture of natural extracts of three medicinal herbs: roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae), and seeds of Cuscuta chinensis Lamark (Convolvulaceae). The root of Morinda officinalis is used to treat rheumatoid arthritis and impotence in traditional oriental medicine. Monotropein and deacetyl asperulosidic acid are the major iridoid compounds in Morinda officinalis. Monotropein was shown to exhibit antinociceptive and anti-inflammatory activities (Choi et al. 2005; Shin et al. 2013). Hyperoside and kaempferol 3-O-glucoside are major flavonoids of the seeds of Cuscuta chinensis, which is an important oriental traditional medicine widely used to improve sexual function, and prevent and treat cardiovascular diseases (Löffler et al. 1997; Yang et al. 2011). The outer scales of onion contain large amounts of quercetin and quercetin 4′-O-glucoside, those are effective antioxidants. Other pharmacologically useful activities, such as liver protection, immune enhancement, anti-infection, anti-stress and anti-cancer effects were also reported (Singh et al. 2009). MOTILIPERM is a novel compound that acts as an antioxidant and is under development for the treatment of male infertility. However, no data are available on the effects of MOTILIPERM on ROS-based ER stress in varicocele-related infertility. Therefore, our aim was to further investigate the mechanism underlying development of male infertility caused by varicocele and to assess the effect of MOTILIPERM in rats with experimentally induced varicocele.
Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells
Published in Pharmaceutical Biology, 2022
Peiyu Wu, Feng Jiao, He Huang, Donghua Liu, Wang Tang, Jie Liang, Wen Chen
The medicinal plant Morinda officinalis F.C. How. (MO) (Rubiaceae) and its root are traditional herbal medicines used as tonics for the treatment of impotence, OP, depression and inflammatory diseases due to their ability to nourish the kidney, strengthen the bone, and improve immunity (Zhang JH et al. 2018). Its polysaccharides are the major chemical compounds isolated from the herb (Zhang JH et al. 2018). Morinda officinalis polysaccharide (MOP) possesses anti-osteoporotic capabilities. In a study, its treatment in ovariectomized rats prevented the deterioration of the rats’ trabecular microarchitecture and reduced bone turnover markers (Zhang D et al. 2020). However, the effect of MOP on GIOP remains largely unknown. To explore the effect of MOP in disease development, a rat model of GIOP was induced and treated with MOP in this study. Exosomes (Exo) are a class of nanosized extracellular vesicles of endocytic origin that exert crucial functions in intercellular communication (Kourembanas 2015). Exo can be secreted into the extracellular milieu and absorbed by target cells, where cellular behaviours are regulated by carrying genetic materials, such as microRNAs (miRNAs) and mRNAs, as well as proteins and liquids (Zhang Y et al. 2019). Exo also exert functions in the bone’s microenvironment and affect bone metabolism (Li Q et al. 2018; Shan et al. 2019) and regulate the communication between osteoblasts and osteoclasts (Yuan et al. 2018). Exo from bone marrow mesenchymal stem cells (BMSCs) alleviated OP by promoting osteoblast activity (Yang et al. 2019). RANKL can induce osteoclastogenesis, and RANKL-treated bone marrow-derived macrophages (BMMs) have been used to mimic osteoclasts for in vitro studies (Park and Yun 2019). In the present study, BMSC-Exo from GIOP rats were extracted to explore their effect on osteoclastic differentiation of RANKL-treated BMMs to determine whether the MOP treatment affected the biological functions of Exo.
The Prevention and Therapy of Osteoporosis: A Review on Emerging Trends from Hormonal Therapy to Synthetic Drugs to Plant-Based Bioactives
Published in Journal of Dietary Supplements, 2019
Twinkle Gupta, Nilanjan Das, Sabiha Imran
Eastern Ghats (India) has plants such as Alangiumsalvi folium, Christiella subpubescens, and Diospyros chloroxylon, which are very effective in treating fractures (Soelaiman, Das, Shuid, Mo, & Mohamed, 2013). Cissus ouadrangularis (family Vitaceae) Asthishunkala is an indigenous medicinal plant of India. The methanolic extract of this plant is responsible for healing the fractured radius ulna of dogs as proved by radiology and histological tests (Richards et al., 2008). Fisetin, an alkaloid found in different plants, showed osteoclast inhibitory effects. Salicornia herbacea extracts are studied to treat osteoporosis. Bone formation enhancement effect of S. herbacea was also confirmed in MC3T3-E1 preosteoblasts (Suneetha, Prasanthi, Ramarao Naidu, & Seetharami Reddi, 2011). Drynaria fortune has therapeutic effects on osteoporosis (Jia et al., 2012). Cimicifuga racemosa contains a number of compounds with potential bioactives such as triterpene, glycosides, resin, salycilates, isoferulic acid, sterols, and alkaloids (Jia et al., 2012). Cimicifuga racemosa does not alter hormonal activity, but it increases bone mineral density. Morinda officinalis is useful in increasing bone mineral density and mineral element concentration and may act both as a suppressor of bone resorption and as an enhancer of bone formation (Jia et al., 2012). Postmenopausal bone loss is associated with estrogen deficiency and leads to excessive osteoclastic and depressed osteoblastic activity. Some phytochemicals, which have antioxidative activity, produce effects that protect bone either by improving antioxidative efficiency or by regulating the activity of osteoblasts and osteoclasts. The leaves of E. brevicornum Maxi., E. sagittatum Maxim, E. pubescens Maxim, E. Wushanense T. S. Ying, and E. Koreanum Nakai have long been used to prevent and treat osteoporosis and other menopause diseases in antiosteoporotic Chinese Traditional medicine formula (Jia et al., 2012). Ginsenoside-Rb2 (Rb2), a 20(S)-protopanaxadiol glycoside extracted from ginseng, is a potent antioxidant. It also shows robust antiosteoporotic activity by means of reducing oxidative stress and inhibiting bone-resorbing cytokines (Karadeniz, Kim, Ahn, Kwon, & Kong, 2014).