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Mycotoxins and Tick-Borne Disease
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
In our practice, we also use stress-reduction techniques (breathing, meditation, prayer, and visualization), pulsed electromagnetic therapy (PEMF), massage, and essential oils very successfully in a multi-modal approach to help patients recover and manage pain without the use of narcotics.
Tinnitus and Hyperacusis
Published in John C Watkinson, Raymond W Clarke, Christopher P Aldren, Doris-Eva Bamiou, Raymond W Clarke, Richard M Irving, Haytham Kubba, Shakeel R Saeed, Paediatrics, The Ear, Skull Base, 2018
Direct electrical stimulation of the ear has been shown to suppress tinnitus but delivering this stimulation is invasive and risks damage to the inner ear.117 Partly because of this tantalizing glimpse of a tinnitus suppressant, other ways of delivering electrical and magnetic energy to the cochlea or central auditory system have been investigated. High-powered rare earth magnets have been placed in the ear canal but an RCT failed to show any benefit despite initial positive reports.118 Electromagnetism has also been investigated: initial trials gave mixed results,119 but the use of refined methods of delivery have promoted further interest in this area. Electromagnetism has been used in conjunction with functional imaging such as PET scanning or fMRI: pathologically active areas of brain are identified and electromagnetic therapy is then directed to this area.120,121 Repetitive transcranial magnetic stimulation (rTMS) can be delivered at a variety of different frequencies and in some circumstances employing complex wave administration.122 A recent Cochrane systematic review has considered the evidence for the administration of rTMS and concluded that there is very limited support for the use of low-frequency rTMS for the treatment of patients with tinnitus.123 When considering the impact of tinnitus on patients’ quality of life, there was support from a single study with a low risk of bias based on a single outcome measure at a single point in time.
Complementary and Alternative Medicine in Older Adults
Published in K. Rao Poduri, Geriatric Rehabilitation, 2017
A small study of 15 women aged 60–70 years were administered pulsed electromagnetic therapy administered at a frequency of 33 Hz and an intensity of 50 gauss for 50 minutes per session, three sessions per week over 3 months. As compared to a control group of 15 women, they demonstrated equivalent improvements in bone mineral density in the neck of the femur and the lumbar spine (L3–L5), as measured by dual-energy x-ray absorptiometry.225
Evaluation of frequency magnetic field, static field, and Temozolomide on viability, free radical production and gene expression (p53) in the human glioblastoma cell line (A172)
Published in Electromagnetic Biology and Medicine, 2020
Ahmad Ashta, Gholamreza Motalleb, Meysam Ahmadi-Zeidabadi
In the present study the effects of SMF (50 G), FMF (10 Hz, 50 G) and temozolomide (200 μm) on life, free radical production, p53 gene and protein expression in human glioblastoma cells (A172) using MTT, NBT, RT-PCR and Western blot were investigated. First, the effect of 20, 40, 80, 100, 200 and 400 μM concentrations of temozolomide with an effective time of 120 hours was investigated. Doses of 200 and 400 μM showed the highest toxicity, with less than 40% of glioblastoma cells surviving after 120 hours. Then, 200 μM of temozolomide and SMF (50 G), FMF (10 Hz, 50 G) were applied to the studied cell line. The results showed that the combination of the drug and the magnetic field had a significant (p ≤ 0.05) lethal effect on the cancer cells compared with the control, drug, and magnetic field alone. On the other hand, the combinational effect of 200 μM of temozolomide and SMF (50 G), FMF (10 Hz, 50 G) was investigated for the free radical production using NBT. Statistical analysis showed that the combination of drug and SMF (50 G), FMF (10 Hz, 50 G) significantly (p ≤ 0.05) increased the production of free radicals in cancer cells compared with the control, drug and magnetic field alone. The results showed that the amount of P53 protein increased significantly (p ≤ 0.05) in A172 cells treated with the combination of drug and FMF (10 Hz, 50 G) compared with the control, drug and magnetic field alone. Amazingly, the combination of temozolomide (200 μm) and the FMF significantly increased (p ≤ 0.05) p53 gene and protein expressions in human glioblastoma cells (A172). Localization of electromagnetic fields can also have potential applications in electromagnetic therapy. Although it is mainly considered to be pseudoscientific with no affirmative ducuments, electromagnetic therapy has been widely practiced and claims to treat diseases by applying electromagnetic radiation to the body. If electromagnetic therapy shall be proven to be impressive, then through the use of certain purposely designed sources, one can generate electromagnetic fields that are concentrated around the diseased area (Berg et al. 2010).