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Published in C. P. Khare, Evidence-based Ayurveda, 2019
The major phytochemical constituents of Alangium salviifolium Linn. are alangine A and B, alangicine, markindine, lamarckinine and emetine. The root of Alangium salviifolium has been used in the Indian system of medicine as an acrid, diuretic, astringent and antidote for several poisons. The fruits (mucosa) of the plant are useful in treating burning sensation and haemorrhages. However, no scientific evidence is available regarding its antimicrobial activity.
A novel hepatoprotective activity of Alangium salviifolium in mouse model
Published in Drug and Chemical Toxicology, 2022
Preeti Dhruve, Mohd Nauman, Raosaheb K. Kale, Rana P. Singh
Alangium salviifolium (L.f.) Wangerin belongs to the genus Alangium and family Alangiaceae. This medicinal plant is distributed across South East Asia, Western Africa, and Australia, and used for medicine in India, China, and Philippines (Kirtikar and Basu 1987). In India, it is found across Bihar, Chhattisgarh, Andhra Pradesh, Tamil Nadu, Kerala, Madhya Pradesh, and Karnataka (Panara et al.2016). Each and every part of this plant finds a mention in Ayurveda and traditional medicine to cure various diseases. In Ayurveda, roots and fruits of A. salviifolium are used to treat rheumatism and hemorrhoids. Traditional healers and local people use roots to manage skin diseases, diarrhea, fever, and blood disorders and as vasodilator; stem to cure diarrhea and vomiting. Leaves are used for the treatment of asthma and rheumatism while fruits are utilized as purgative, expectorant, carminative, and antidote against poisoning (Tanwer and Vijayvergia 2014). In Chhattisgarh, a state of India, it is commonly known as ankol or akol, and root, bark, and fruits of this plant are being used traditionally for cancer treatment (Jain and Jain 2010).
Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Salicin is a prodrug of acetylsalicylic acid, a main constituent of aspirin and can be derived from the stems and roots of Alangium chinense (Lour.) Harms. (Alangiaceae), a common evergreen shrub native to east and southeast Asia [1]. Alangium chinense has long been used in traditional Chinese medicine (TCM) to treat rheumatic disease, snake bites, circulatory issues, hemostasis, and toxicity, it is also used as a contraceptive or analgesic and to promote wound healing [2,3]. Records of the use of willow bark, another common source of salicylic acid, have been found dating back to the 3rd century B.C. [4]. Numerous substances can be derived from the rhizome, roots, stems, leaves, or flowers of Alangium chinense such as alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones, and glycosides including salicin [2,5,6] Recently, research has focused on methods of extraction of salicin and its potential therapeutic applications [6–8] As a prodrug, salicin is hydrolyzed to salicyl alcohol and then oxidized to salicylic acid in the gut [9]. As a metabolite of salicin, salicylic acid inhibits the activity of cyclo-oxygenase (COX), which plays a major role in regulating pain, fever, and inflammation by metabolizing arachidonic acid, a prostaglandin precursor [10]. However, to the best of our knowledge, this is the first time that the potential effects of salicin have been explored in osteoarthritis (OA). OA is characterized by chronic inflammation and irreversible cartilage destruction, which takes a massive toll on patients’ quality of life and mobility. The main risk factor for OA is age, in part due to the accumulation of advanced glycation end-products (AGEs). AGEs came to exist in the body as a byproduct of the innate process of non-enzymatic glycation as well as via dietary intake, as AGEs are used as a food preservative owing to their high resilience to degradation [11,12]. Some of the factors involved in the development and progression of OA include oxidative stress, secretion of proinflammatory cytokines, recruitment of immune cells, degradation of cartilage and activation of proinflammatory signaling pathways, all of which are demonstrated to be triggered by exposure to AGEs.