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Crohn's Disease
Published in Charles Theisler, Adjuvant Medical Care, 2023
Diet: Protein-energy malnutrition and suboptimal weight is reported in up to 85% of patients with Crohn’s disease.2 A low-roughage diet that is high protein, low fat, and milk free often provides symptomatic relief in patients with mild to moderate disease or in patients with strictures.3
Nutrition
Published in Barbara Smith, Linda Field, Nursing Care, 2019
Fibre is a complex carbohydrate derived from plants. Humans are unable to digest fibre, although it provides important roughage, or bulk, in the diet. This roughage helps to satisfy the appetite and assists the digestive tract to function well and eliminate waste products. Fibre occurs in the skin, seeds and pulp of many fruits and vegetables and in the outer layer of grains and bran.
Colon Cancer Epidemiology
Published in Herman Autrup, Gary M. Williams, Experimental Colon Carcinogenesis, 2019
“Roughage” in the diet was suggested to be protective against colon cancer already by Higginson and Oettle33 in the 1960s, and Burkitt later suggested that a low content of dietary fiber in the western diet would be responsible for the high colon cancer risk in that part of the world.29
Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota
Published in Gut Microbes, 2020
Vishal Singh, Beng San Yeoh, Ahmed A. Abokor, Rachel M. Golonka, Yuan Tian, Andrew D. Patterson, Bina Joe, Mathias Heikenwalder, Matam Vijay-Kumar
Inulin, a polyfructosan (Orafti® HP; source: chicory root; inulin content: 100%; degree of polymerization: > 23) was procured from Beneo (Tienen, Belgium). Inulin was incorporated into an open-source diet, i.e. inulin-containing diet (ICD: cat# D12081401) comprised of 7.5% inulin and 2.5% cellulose. Cellulose was retained in the diet to maintain roughage. Deoxycholate was procured from Sigma and supplemented into ICD (at 0.3% w/w) to formulate Deoxy-ICD diet (cat# D18112901). Diet was prepared by Research Diets (New Brunswick, NJ) and their composition is provided in detail in Singh et al..9