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Catalog of Herbs
Published in James A. Duke, Handbook of Medicinal Herbs, 2018
“Contains the glycosides, quercetin 3-arabinoside and avicularin” (C20H19O11).8 Also, contains calcium oxalate, polygonic acid, salicic acid, tannic acid, and a trace of volatile oil. Avicularin, catechin, delphinidin, hyperin, myricetin, querciten, quercitrin, and rutin are also reported.12,33 Roots contain 0.35% oxymethylanthraquinone, twigs 0.2%, leaves 0.15%.3
The Chemistry and Biological Activity of the Genus Bupleurum in Italy
Published in Sheng-Li Pan, Bupleurum Species, 2006
In the course of investigations on the chemical constituents of some Bupleurum species of the Italian flora, Pistelli et al. (1996) took into consideration B. falcatum L. subsp. cernum, from which some flavonoids together with the just mentioned saponins, were isolated. Rutin and two other quercetin glycosides, avicularin (3-α-L-arabinofuranoside) (13), and guaijaverin (3-α-L-arabino pyranoside) (14), were isolated and identified from the ethyl acetate extract. Their structures were confirmed by NMR spectral analysis and acid hydrolysis and by comparison with the literature data. Both latter compounds were isolated previously from Andromeda polifolia L. (Pachaly and Klein, 1987), but this was the first report of their presence in the genus Bupleurum.
Phytochemical profile, enzyme inhibition activity and molecular docking analysis of Feijoa sellowiana O. Berg
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Fatema R. Saber, Rehab M. Ashour, Ali M. El-Halawany, Mohamad Fawzi Mahomoodally, Gunes Ak, Gokhan Zengin, Engy A. Mahrous
Feijoa leaves extract was found to be rich in phenolic content as determined by the Folin–Ciocalteu method which estimated the phenolic content per gram of the extract at 128.87 ± 0.92 mg GAE. Additionally, relatively high flavonoid content was also reported for the extract at 71.37 ± 0.23 mg RE per gram of extract. This was supported by thorough phytochemical investigation of Feijoa extract which resulted in the isolation of several compounds including; α-tocopherol F1 and four flavonoids, namely, flavone F2, primetin F3, quercetin F4, and its 3-O-arabinofuranoside glycoside (avicularin), F5 (Figure 1). These compounds were identified based on co-chromatography with authentic compounds, as well as, their characteristic NMR spectra, being compared with the available literature8,11,20. NMR data are presented in Tables S2 and S3 (provided in the supplementary file). Among these compounds, avicularin has been previously identified as a major metabolite of Feijoa leaves8,13, while vitamin E (α-tocopherol), flavone and quercetin were previously reported in both leaf and fruit extracts12,21. Additionally, one triterpene, β-amyrin, F6 and two phytosterols: β-sitosterol, F7 and β-sitosterol glucoside, F8 were isolated and identified based on their 1H-NMR and 13 C-NMR and by comparison with the current available literature21,22.
Effects of Lespedeza Cuneata aqueous extract on testosterone-induced prostatic hyperplasia
Published in Pharmaceutical Biology, 2019
Bong Kyun Park, Chang Won Kim, Jeong Eun Kwon, Manorma Negi, Yong Tae Koo, Sang Hun Lee, Dong Hyun Baek, Yoo Hun Noh, Se Chan Kang
Lespedeza cuneata G. Don (Fabaceae) is a species of flowering plant native to Asia and eastern Australia. L. cuneata is used as a traditional herbal medicine for asthma, abscesses, breast cancer, and protection of liver and kidney function (Ahn 1998). Several studies have indicated that it has therapeutic effects on diabetes, low stamina and amblyopia (Huang 1998). Its bioactive components include β-sitosterol, quercetin, kaempferol, pinitol, avicularin, juglanin and trifolin, among others (Matsuura et al. 1978). These are known to have antioxidant, anti-inflammation and anticancer effects. In particular, β-sitosterol has the potential to inhibit BPH and high blood cholesterol levels (Wilt et al. 1999; Rudkowska et al. 2008). Roots and leaves of L. cuneata also contain minerals, amino acids, vitamins and flavonoids, suggesting that extracts of the leaves may have antioxidative and anti-inflammatory effects (Ding et al. 2006; Deng et al. 2007; Kim & Kim 2010). Although many previous studies have examined the pharmacological effects of L. cuneata, the pharmacological effects of an aqueous extract of L. cuneata (LCW) on testosterone-induced prostatic hyperplasia (TPH) have not been explored.