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Cardiovascular system
Published in Jagdish M. Gupta, John Beveridge, MCQs in Paediatrics, 2020
Jagdish M. Gupta, John Beveridge
8.8. Right ventricular hypertrophy in childhood isa characteristic feature of transposition of great vessels.a characteristic feature of tetraology of Fallot.a characteristic feature of tricuspid atresia.diagnosed when the Τ wave is upright in VI after 72 h of age.diagnosed when R in VI exceeds 20 mm.
Cardiology
Published in Fazal-I-Akbar Danish, Essential Lists of Differential Diagnoses for MRCP with diagnostic hints, 2017
Congenital cyanotic heart diseases:1 Right-to-left shunt: a Fallot’s tetralogy.b Transposition of great vessels.c Severe Ebstein’s anomaly.2 Without a shunt: a Tricuspid atresia.b Severe pulmonary stenosis.c Pulmonary atresia.d Hypoplastic left heart.3 Reversal of a previous left-to-right shunt (d/t ASD, VSD, PDA): a Eisenmenger’s syndrome.
Test Paper 1
Published in Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike, Get Through, 2017
Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike
A 3-year-old child with shortness of breath is diagnosed with tetralogy of Fallot. All of the following abnormalities may be associated with this condition, except Transposition of great vessels (TGA)Patent ductus arteriosus (PDA)Anomalous origin of coronary arteriesDiGeorge syndromeRight-sided aortic arch
Risks of molecular targeted therapies to fertility and safety during pregnancy: a review of current knowledge and future needs
Published in Expert Opinion on Drug Safety, 2021
Elena Lorenzi, Matteo Simonelli, Pasquale Persico, Angelo Dipasquale, Armando Santoro
As easily conceivable, data for the newer second-generation Bcr-Abl-I nilotinib and dasatinib are sparse. In a case report by Abruzzese and colleagues, a 33-year-old male patient with CML who was enrolled in the GIMEMA NILIM trial (alternated nilotinib/imatinib), conceived after 40 days of nilotinib treatment and had a healthy boy born at term [36]. The investigator brochure (issued on 8 June 2012) refers to a total of 36 cases of drug exposure via the father. One of these cases presented with fetal abnormalities and ended with a therapeutic abortion [36]. Considering maternal exposure, nilotinib investigator’s brochure reported 45 cases of drug exposure during pregnancy [36]. There was only one case with fetal abnormalities. In addition, there was one pregnant female carrying twins who was exposed; one twin experienced congenital transposition of great vessels and resulted in death, and the other twin experienced a non-serious heart murmur [36].
A rare case of adult congenital heart disease: single ventricular chamber with anomalous right coronary artery in an octogenarian
Published in Journal of Community Hospital Internal Medicine Perspectives, 2019
Muhammad Shabbir Rawala, Amna Saleem Ahmed, Syed Bilal Rizvi
An 81-year-old female presented to the emergency department (ED) with chest pain. She had a past medical history of type II diabetes mellitus, hypertension, and polycythemia. She did have a family history of coronary artery disease. She was evaluated in ED as non-ST elevation myocardial infarction due to elevated troponins. The patient was initially administered antiplatelets and anticoagulation. On examination, the patient had hypoxia with a saturation of 80% on room air, cyanosis, mild JVD, edema and ejection systolic murmur. On further questioning, patient had dyspnea on exertion, mild swelling and cyanosis of extremities with exercise intolerance. The echocardiogram revealed a single ventricle which was thought to be left ventricle with possible transposition of great vessels. (Figure 1)
Antenatal Diagnosis of Fetal Retinoid Syndrome at 20 Weeks of Gestation: A Case Report
Published in Fetal and Pediatric Pathology, 2018
Hakan Erenel, Aysegul Ozel, Funda Oztunc, Osman Kizilkilic, Nil Comunoglu, Seyfettin Uludag, Riza Madazli
Retinoids are a specific family of vitamin A derivatives including several subtypes such as first, second and third generation. Retinol, retinal, tretinoin (retinoic acid), isotretinoin, and alitretinoin are first generation retinoids. Etretinate and its metabolite acitretin are second-generation retinoids (4). Adapalene, bexarotene, and tazarotene are third generation retinoids (5). Retinoids are used in several conditions such as acne, psoriasis and cancer. One of these retinoids is isotretinoin (13-cis-retinoic acid), which was licensed in the United States in 1982 under the brand name Accutane (2). In 1985, Lammer et al. summarized outcomes of 154 pregnant patients with the exposure to isotretinoin (2). After excluding elective and spontaneous abortions, analysis of 21 malformed infants showed that most common craniofacial malformation was microtia or anotia. Maldevelopment of facial bones and calvarium, micrognathia, cleft palate, flat and depressed nasal bridge, hypertelorism, cerebellar hypoplasia, agenesis of the vermis were described cranial anomalies. They also reported several forms of conotruncal malformations such as transposition of great vessels, tetralogy of Fallot, double-outlet right ventricle, truncus arteriosus communis and supracristal ventricular septal defect in conjunction with abnormalities of thymic morphogenesis (ectopia, hypoplasia, aplasia) (2). In our case, fetal anomalies were observed in most of the above-mentioned regions.