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Anesthesia Monitoring and Management
Published in Michele Barletta, Jane Quandt, Rachel Reed, Equine Anesthesia and Pain Management, 2023
Monitoring is necessary to ensure the safe outcome of an anesthetic episode and to recognize potential complications and institute treatment in a timely fashion. Monitoring guidelines for horses undergoing general anesthesia are available on the American College of Veterinary Anesthesia and Analgesia website (www.acvaa.org/docs/Equine).
Surgical Facilities, Peri-Operative Care, Anesthesia, and Surgical Techniques
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Alison C. Smith, M. Michael Swindle
Inhalational anesthesia should be the primary choice for general anesthesia unless it is con-traindicated by the scientific protocol or the inability of laboratory personnel to administer it properly. The most commonly used inhalant anesthetics in veterinary anesthesia are isoflurane, halothane and methoxyflurane. Other newer agents include desflurane, sevoflurane and enflurane. Older agents such as ether and chloroform should not be considered for general anesthesia. The agent that has the most widely indicated applications is isoflurane. It provides surgical anesthetic levels at concentrations ranging from 0.5-2.0% in most species. Nitrous oxide does not provide sufficient analgesia as a sole agent for general anesthesia in animals and should only be used in combination with other agents to reduce the level of the inhalant required.11-16,22
Tolerability of long-term temperature controlled whole-body thermal treatment in advanced cancer-bearing dogs
Published in International Journal of Hyperthermia, 2022
B. Wylleman, L. Brancato, I. Gorbaslieva, E. van Zwol, M. G. M. C. Mori da Cunha, J. Benoit, D. Tierny, P. Vueghs, J. Van den Bossche, O. Rudenko, M. Janicot, J. Bogers
The WBTT was strictly performed under general anesthesia with the supervision of an EBVS European Specialist in Veterinary Anesthesia and Analgesia. Ketamine-propofol mixture (1.0 and 2.0 mg/kg, respectively) was used to induce the anesthesia. Dog patient was placed inside the HyperTherm and respective sensors were connected. Dog patient was intubated and mechanically ventilated to regulate the evacuation of CO2. Effective neuromuscular blockage was required to prevent counter breathing. Anesthesia was maintained with isoflurane (1.75–3%) in O2 (1–3 L/min). Each treatment was composed of three phases: (1) heating phase (at a rate of 1 °C increase per 30 min); (2) plateau phase at a body temperature of 41.5 °C; and (3) cooling phase. Vital parameters were monitored during the entire procedure, in function of the need for deep anesthesia with good muscle relaxation, cardiovascular support with adequate fluid and vasopressor adjustment, and ventilatory compensation of metabolic changes. Blood sampling was performed once during the heating phase, and every 2 h after stabilization (plateau phase − 41.5 °C), at 24 h, 48 h and 14 days after WBTT. These blood samples were analyzed in house for routine hematological and biochemical parameters, cardiac troponin I and electrolytes. Additionally, coagulation times (activated partial thromboplastin time (aPTT) and prothrombin time (PT)) were determined. After the treatment, animals were hospitalized for 2 more days to continue fluid therapy, and to allow clinical monitoring and blood sampling.
Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways
Published in Pharmaceutical Biology, 2018
Kiran Kumar Soni, Li Tao Zhang, Bo Ram Choi, Keshab Kumar Karna, Jae Hyung You, Yu Seob Shin, Sung Won Lee, Chul Young Kim, Chen Zhao, Han-Jung Chae, Hye Kyung Kim, Jong Kwan Park
Rats were anesthetized with a mixture of ketamine (100 mg/mL) and 2% xylazine hydrochloride (20 mg/mL). The mixture (170–230 μL/100 g body weight) was administered intramuscularly on the side of the back paw. According to veterinary anaesthesia and analgesia, stage III anaesthesia was determined by the presence of unconsciousness with progressive depression of reflexes. Muscular relaxation developed in the rats and ventilation slowed but remained regular. The vomiting and swallowing reflexes were also lost.
The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats
Published in Nutritional Neuroscience, 2020
Ipek Acar, Alper Cetinkaya, Incilay Lay, Esin Ileri-Gurel
Alper Cetinkaya is an associate professor of Veterinary Clinical Sciences Surgery. He has been working at Hacettepe University Laboratory Animal Applications and Research Center since February 2018. His research interests focus on Veterinary Orthopedics and Traumatology, Veterinary Surgery, Veterinary Radiology, Veterinary Anesthesia and Reanimation.