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Vascularization of the Intrahepatic Biliary Tree and Its Role in the Regulation of Cholangiocyte Growth
Published in Gianfranco Alpini, Domenico Alvaro, Marco Marzioni, Gene LeSage, Nicholas LaRusso, The Pathophysiology of Biliary Epithelia, 2020
Eugenio Gaudio, Paolo Onori, Antonio Franchitto, Roberta Sferra, Antonella Vetuschi, Sergio Morini, Gianfranco Alpini, Domenico Alvaro
At the periphery of the lobule there is a very thin empty zone without any characteristic vascular element. Three weeks after common BDL, a typical well-developed peribiliary microvascular plexus, originating from arterioles derived from hepatic arterial branches is observed. The plexus runs at the periphery of the lobule and appears hypertrophic but otherwise normal in its arrangement (Fig. 3). The plexus is composed of many layers and shows an intimate meshed network, characterized by round loops, resembling the organization of the inner vascular layer of the extrahepatic peribiliary plexus (Fig. 4). Between the peribiliary plexus and the sinusoidal network there is an empty space, which corresponds to proliferating connective tissue, digested during the casting procedure (Fig. 5). Infrequent vascular communications between the peribiliary plexus and sinusoids are also visible. The efferent vessels that arise from the confluence of the capillaries form a small vein that tends to drain into the interlobular vein. In some areas of the liver the peribiliary plexus does not seem to develop completely in 3 week BDL rats. In these areas there is a typical neovascular organization with interrupted vascular loops and dead-end vessels (Fig. 6). These structures may represent an attempt to increase metabolic exchange within the ductular lumen and peribiliary plexus.6
Pancreas Microcirculation
Published in John H. Barker, Gary L. Anderson, Michael D. Menger, Clinically Applied Microcirculation Research, 2019
Michael D. Menger, Brigitte Vollmar
The vascular supply of the pancreas includes pancreaticoduodenal and splenic, as well as gastric, omental, and epiploic vessels. The unit of a pancreatic lobule (acinar tissue) is fed by two intralobular arteries, branching from interlobular vessels, which then form terminal arterioles, breaking into a honeycomb-like capillary network with the junctions about 25 to 50 µm apart. In addition to these nutritive supply vessels, terminal arterioles also continue with an arcade-like vessel, which allows the blood to bypass the capillaries as a preferential pathway. From capillaries (4–8 µm in diameter), as well as from preferential pathways (9 µm in diameter), blood is drained into postcapillary venules and, finally, into intralobular and interlobular veins.1
Tropical infections and infestations
Published in Professor Sir Norman Williams, Professor P. Ronan O’Connell, Professor Andrew W. McCaskie, Bailey & Love's Short Practice of Surgery, 2018
Professor Sir Norman Williams, Professor P. Ronan O’Connell, Professor Andrew W. McCaskie
Having entered the portal circulation, the trophozoites are filtered and trapped in the interlobular veins of the liver. They multiply in the portal triads, causing focal infarction of hepatocytes and liquefactive necrosis as a result of proteolytic enzymes produced by the trophozoites. The areas of necrosis eventually coalesce to form the abscess cavity. The term ‘amoebic hepatitis’ is used to describe the microscopic picture in the absence of macroscopic abscess, a differentiation only in theory because the medical treatment is the same.
Protective and Curative Effects of Aqueous Extract of Terfezia Boudieri (Edible Desert Truffle Specie) against Paracetamol Acute Toxicity in the Rat
Published in Nutrition and Cancer, 2021
Ezzeddine Nouiri, Ridha Ben Ali, Ridha Ghali, Manel Araoud, Michele Véronique El May, Abderrazek Hedhili
It is known that PCM presents a renal toxicity (37) and to prove that the protective and curative effects of TBAE were not specific to hepatocytes, it was necessary to evaluate the degree of toxicity on renal tissue. An over dose of PCM lead to large dilations of distal convoluted tubules and interlobular veins. The pretreatment with TBAE prevents PCM kidney toxicity proved by normal renal aspect with absence of injuries observed in group G2. In the curative model, the results showed normal kidney tissue with conserved glomeruli and some rare necrosis area. This proves the capacity of TBAE to protect against toxic effect of PCM. However, the treatment by NAC drug did not protect kidneys and resulted in a marked necrosis in the cortex corticis, important dilations of distal convoluted tubules, collecting tubules and interlobular veins. This result points out the ability of thiols (NAC our study) to act as pro-oxidant molecules (35).
Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice
Published in Islets, 2018
Wataru Nishimura, Asako Sakaue-Sawano, Satoru Takahashi, Atsushi Miyawaki, Kazuki Yasuda, Yasuko Noda
Anatomically, blood supplies from the major arteries of the pancreas flow into the interlobular arteries, arterioles and capillaries, reaching the islets through a glomerular-like network where they are collected mostly by interlobular veins.1,18 Our method cannot distinguish between arteries and veins, but it can demonstrate the pancreas microvasculature. Additionally, we cannot capture the blood perfusion in the islets, which may flow from the periphery to the center or from the center to the periphery. Dynamic imaging system with fluorescent proteins in vivo is required to clarify of blood flow in pancreas. We also could not visualize morphological relationship between β-cells and vessels in detail, which needs the system with much higher resolution.
Catastrophic antiphospholipid syndrome in a patient with systemic sclerosis and hereditary angioedema: case report and literature review
Published in Modern Rheumatology Case Reports, 2018
Jean Liew, Marcia Friedman, Sima Desai, Lindsay Taute, Nastaran Neishaboori, Peter Stenzel, Ajay Wanchu
On hospital day 25, the patient developed acute dyspnoea leading to fatal pulseless electrical activity cardiopulmonary arrest. Autopsy did not reveal any pulmonary, cardiac, or central nervous system infarcts to account for her rapid demise, although the findings of splenic and hepatic infarcts supported the clinical diagnosis of CAPS (Figure 4). The diagnosis of SSc was supported by findings of skin and pulmonary involvement with epidermal atrophy, dermal fibrosis, focal pulmonary fibrosis, and myofibroblastic obliteration of the interlobular veins in the lungs. No microscopic involvement of either the glomeruli or oesophagus was seen. The ultimate cause of death was felt to be from CAPS.