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Genetics
Published in Manoj Ramachandran, Tom Nunn, Basic Orthopaedic Sciences, 2018
Peter Calder, Harish Hosalkar, Aresh Hashemi-Nejad
Marfan’s syndrome. Mutation in the gene fibrillin-1 (which acts as a Chinese finger trap around collagen) causes a defect in scaffolding for elastic tissues in the body. Clinical features include myopia, lens dislocation (superiorly), retinal detachment, aortic regurgitation, dissecting aortic aneurysm and mitral valve prolapse. Prominent skeletal issues are joint laxity, protrusio acetabuli and scoliosis. Bracing is recommended for progressive curves, many of which will require surgical fusion. Early echocardiogram and eye examination are part of routine care.
Three-dimensional scanner with a modified evaluation method for measuring hand edema subtitle: an idea for accurate evaluation and preliminary fundamental and clinical validation
Published in Journal of Plastic Surgery and Hand Surgery, 2023
Shimpo Aoki, Hisato Nagano, Tomoharu Kiyosawa, Yoshifumi Tsuda, Ko Izumiyama
This study has some limitations. We only evaluated life-sized plastic models and one clinical case of subacute edema of the hand as a preliminary study. To establish this method for clinical use, further evaluations are required, including an assessment of the relationship between edema and intra-muscular pressure in cases of acute injury. This would also allow us to see if our 3D scanner can be used as a clinical tool in chronic lymphedema, which needs long term treatment; therefore, we need to assess the long-term validity and reliability of this technique in the outpatient department. As the difference in variance between the male and female models revealed, the position of the hand also critically influences accurate evaluation of edema. Consequently, stabilizing the position of the hand must be critical in this method. In unconscious patients with severe injuries, additional use of a Chinese finger trap fixation might solve this position problem, especially during MM.