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Psychiatric symptoms
Published in Dinesh Kumar Jain, Homeopathy, 2022
Facts about delirium should be known to all. “It is not too unusual for delirium to come and go without a specific cause being identified” (Wells, 1985, p. 848). Actually,Acute brain disorders are caused by diffuse impairment of brain function. Such impairment may result from a variety of conditions including high fevers, nutritional deficiency and drug intoxication. Symptoms range from mild mood changes to acute delirium. The prognosis in acute brain disorder is good. Such conditions usually clear up over a short period of time.(Coleman, 1976, p. 460)
Physiology of ageing, risk factors and rehabilitation
Published in Rebecca Allwood, Working with Communication and Swallowing Difficulties in Older Adults, 2022
Although age-related decline can be separated into physical and cognitive decline, there are clear interactions between the two with changes to brain function affecting physicality as well as cognitive function. An investigation by Auyeung et al. (2011) found association between physical frailty in cognitively normal older adults and their future cognitive decline. Loss of physical ability can lead to fewer opportunities for social interaction, which can in turn lead to cognitive decline.
Elderhood
Published in Julia Whitaker, Alison Tonkin, Play for Health Across the Lifespan, 2021
Throughout our lives, the brain changes more than any other part of the body and, as with all other body systems, increasing age sees a natural decline in brain function (Nichols 2017). The older brain is characterized by cognitive decline which manifests in altered functionality: ‘our ability to think slows down, and we may experience occasional difficulty in, for example, recalling where we left our keys or retrieving a word or name. By all accounts, this is considered a normal degree of cognitive decline’ (Morris 2018 Kindle Loc 81).
Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial
Published in Journal of Dietary Supplements, 2023
Anne C. Curtin, Carol S. Johnston
In addition to the tryptophan-kynurenine pathway, PLP is an essential coenzyme for hundreds of biochemical reactions, including the L-amino acid decarboxylase-dependent conversion of tryptophan to serotonin (11, 12). Serotonin, along with other neurotransmitters, is important for brain function and the regulation of mood (13, 14). Low plasma PLP has been linked to low serotonin concentrations in the brain and to depressed mood (15, 16). Although there is much literature confirming the link between vitamin B6 deficiency and depression, as well as the link between decreased vitamin B6 status and oral contraceptive use, the current literature fails to identify a direct connection between plasma PLP concentrations and mental health in young women who use oral contraceptives. Investigating this direct link could help determine whether vitamin B6 supplementation is advantageous for improving symptoms of depression and mood states of young women on oral contraceptives.
Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ®)
Published in Toxicology Mechanisms and Methods, 2022
Yoshiaki Shiojima, Narendra Deshmukh, Hiroyoshi Moriyama, Yogini Soman, Prashant Nalge, Manisha Randhe, Jaideep Kanhere, Aasavari Karmarkar, Manashi Bagchi, Debasis Bagchi
In recent years, incidence of cognitive decline, dysfunctions, and impairments is increasing dramatically leading to a remarkable increase in healthcare cost. In fact, this alarming increase in the prevalence of dementia is now a worldwide epidemic and a global emergency and threat (Feigin et al. 2020). In fact, the scientific communities are exploring preventive strategies for improving brain function and performance. Enhanced oxidative stress and insulin resistance initiate inflammatory responses, mitochondrial dysfunction, and neurodegeneration process with advancing age (Asada 2013; Prince et al. 2015; Subhan and Bagchi 2017; Crawford et al. 2020; Chen and Yoshida 2021; Kumar and Bagchi 2021). The protective abilities of diverse fresh food, vegetables, and structurally diverse natural popular antioxidants and neuroprotectants have been well documented (Akagawa et al. 2016; Subhan and Bagchi 2017; Kumar and Bagchi 2021; Shiojima et al. 2021).
Biomarkers of disease in human nails: a comprehensive review
Published in Critical Reviews in Clinical Laboratory Sciences, 2022
Sarahi Jaramillo Ortiz, Michael Howsam, Elisabeth H. van Aken, Joris R. Delanghe, Eric Boulanger, Frédéric J. Tessier
Psychological and neurological disorders include dementia, characterized by age-related deterioration of brain function and of which AD is among the most common condition. A recent review surveyed biomarkers of AD in both classical and noninvasive matrices; low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol, thyroid-stimulating hormone, ferritin, homocysteine, albumin, as well as the analysis of several elements in nails were all covered, but no correlations with incidence or severity of the disease were reported [102]. In the same vein, Kuyumcu et al. [103] found very similar levels of Zn in their case-control study of fingernails of elderly AD patients. Nevertheless, a more recent small, case-control study (n = 40) reported that median concentrations of both As and Se were higher in fingernails from AD patients than controls [104]. Using ICP-MS analyses, the difference for both elements was greater when “severe” AD patients were compared (factor of ∼5), but even “mild” AD patients had concentrations of As and Se 2–3 times those found in fingernails from healthy controls. In addition, a positive association between concentrations of these elements was evident only among the AD cases, though whether these were cause or consequence of AD remains unclear.