Maximum lifespan

Maximum lifespan

Maximum lifespan refers to the longest possible duration that a living organism or product can exist, with examples ranging from 50 years for a recommended product lifespan to 125 years for the maximum lifespan of a human being. It can also vary greatly between species, with some animals having a maximum lifespan of only a few years while others can live for over a century.From: Constructional Steel Design [2019], Some aspects on the sustainable process design in a timber mill using the design for manufacturability/sustainability [2020], Enterprise Agility in Healthcare [2018], A new approach method for characterizing inter-species toxicodynamic variability [2021]

Introduction

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Published in John G. Stenbeck, Lauren E. Mix, Enterprise Agility in Healthcare, 2018

John G. Stenbeck, Lauren E. Mix

Despite healthcare’s amazing success in improving the quality and average lifespan of human beings, the maximum lifespan remains unchanged at no more than 125 years. Very few healthcare organizations live for much longer, with most disappearing before reaching one-third of that lifespan.

A new approach method for characterizing inter-species toxicodynamic variability

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Published in Journal of Toxicology and Environmental Health, Part A, 2021

Sarah D. Burnett, Moumita Karmakar, William J. Murphy, Weihsueh A. Chiu, Ivan Rusyn

Previous investigators used dermal fibroblasts from up to 58 avian and mammalian species to investigate inter-species differences in sensitivity to chemical-induced effects (n = 8 chemicals) (Harper et al. 2011). This study aimed to diversify both the species tested and chemical space to assess interspecies variability in toxicodynamic responses. Thus, our study encompassed a broad diversity of species that varied in taxonomy, lifespan, and body weight characteristics (n = 54) and chemicals (n = 40) (Figure 1). Species included birds (n = 3) and mammals of the orders Primates (n = 21), Carnivora (n = 11), Rodentia (n = 9), Cetartiodactyla (n = 8), Marsupialia (n = 1), and Lagomorpha (n = 1). The species ranged in maximum lifespan from 3.8 years (rat) to 122.5 years (human) and encompassed several orders of magnitude in average body weight, from 0.0193 kg (mouse) to 493 kg (camel). In addition, inclusion of cells from multiple humans (n = 7) and standard preclinical species (rat, n = 4; dog, n = 3; monkey, n = 4) enabled assessment of inter-individual variability for each species.

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Introduction

A new approach method for characterizing inter-species toxicodynamic variability