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Use of Halo-tolerant Bacteria to Improve the Bioactive Secondary Metabolites in Medicinally Important Plants under Saline Stress
Published in Ajar Nath Yadav, Ali Asghar Rastegari, Neelam Yadav, Microbiomes of Extreme Environments, 2021
The composition of essential oil in a plant mostly depends on the metabolic and physiological state of the plant. Plant inoculated with halo-tolerant bacteria has enhanced production of secondary metabolites including essential oil, which directly depends on primary metabolites and nutrient status of the plant (Jha and Subramanian 2016). Analysis of other important secondary metabolites like total steroid, alkaloid withanolide A and withaferin A has also been estimated and results have shown that both inoculation with halo-tolerant bacteria as well as stress, were able to enhance the production of these secondary metabolites (Table 4.4). So for the biosynthesis of a large variety of secondary metabolites, plants act as a chemical factory in which the root-associated bacteria act as a catalyst. These secondary metabolites are used as pesticides, scents, medicines, dyes and has many other commercial uses Secondary metabolites are not essential for plant growth, but are produced by the plant for its survival under stress. Adverse environmental signals like carbon-nutrition imbalance, ontogenesis, abiotic and biotic stimuli, are usually responsible for the production of secondary metabolites in plants (Mary Ann Lila 2006). Co-evolution between plants and their microbial partners is a mediator for plant chemical defense and for the protection of plants.
Phytochemical and biological characterization of aqueous extract of Vassobia breviflora on proliferation and viability of melanoma cells: involvement of purinergic pathway
Published in Journal of Toxicology and Environmental Health, Part A, 2023
Altevir Rossato Viana, Nathieli Bianchin Bottari, Vinícius Rodrigues Oviedo, Daniel Santos, James Eduardo Lago Londero, Maria Rosa Chitolina Schetinger, Erico Marlon Moraes Flores, Aline Pigatto, André Passaglia Schuch, Alexandre Krause, Luciana Maria Fontanari Krause
Vassobia breviflora belongs to the Solanaceae Family, which comprises approximately 2700 species of plants adapted to different regions, and cultivated for foods including pepper, potato, tomato and eggplant, medicinal/recreational uses such sas belladonna, tobacco, mandrake, and cork tree, as well as ornamental petunia and brunfelsia (Cericola et al. 2013; Knapp et al. 2013). Vassobia breviflora is also known in southern Brazil as “Esporão-de-galo” and characterized as a thorny shrub, present in southern and southeastern Brazil, Uruguay, Paraguay, Argentina, and Bolivia. The cytotoxicity attributed to V. breviflora against cancer cells was investigated for the first time in a study carried out in Argentina, with the isolation and identification of the active principle Withaferin A through techniques such as mass spectrometry, high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR), and silica plates. The bioactive Withaferin A was isolated from the aerial parts of V. breviflora and showed which caused antiproliferative activity in head and neck squamous cell carcinoma cells, by inducing apoptosis (Samadi et al. 2009, 2010). Similar results were found against thyroid cancer cells, in which plant-derived bioactive compounds reacted with proteins involved in the disease. Taking into consideration the various studies that demonstrated the importance of plant-derived substances from the Solanaceae family including Withaferin A to effectively treat various diseases including epilepsy, depression, arthritis, diabetes and palliative effects (Dutta et al. 2019) as well as the antitumoral actions of this plant suggested that derivatives of this Solanaceae might be considered as possible candidate for antitumor therapy (Grogan et al. 2013; Samadi et al. 2012).
Cytotoxic screening and antibacterial activity of Withaferin A
Published in Journal of Toxicology and Environmental Health, Part A, 2022
Altevir Rossato Viana, B. Godoy Noro, J. C. Lenz, M. Luiza Machado Teixeira, M. Bolson Serafin, R. Hörner, C. Franco, L. Maria Fontanari Krause, B. Stefanello Vizzotto, B. Jalfim Maraschin
Withaferin A (WA), a 28-carbon steroid lactone, the bioactive component of Withania somnifera (Solanaceae family) has been widely studied for its antitumor (Dutta et al. 2019; Hassannia et al. 2020; Tandon et al. 2020) and antibacterial (Arora et al. 2004; Pandit, Song, and Jeon 2014; Rahman and Khan 2020) actions. Based upon these biological properties, this study examined the in vitro effects of WA on cell viability using tumor cell lines cell viability and antibacterial activity utilizing pathogenic microorganisms.