Thiocarbamate

Thiocarbamate

Thiocarbamate is a chemical compound that is formed by substituting one or both of the oxygen atoms in a structure with sulfur. It is commonly used as a pharmacophore in a variety of herbicides, insecticides, bactericides, fungicides, and anti-viral agents. Many specific examples of thiocarbamates are used as fungicides and herbicides, such as ferbam, mancozeb, maneb, thiram, butylate, pebulate, metham, molinate, cycloate, and vernolate.From: Handbook of Environmental Analysis [2017], Toxicology and Risk Assessment [2019], Modified Riemschneider reaction as a new route for the synthesis of coumarinyl and 1-aza coumarinyl thioethers [2019]

Pesticides and Chronic Diseases

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Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017

William J. Rea, Kalpana D. Patel

Except for some moderate irritant effects on skin, respiratory tract, and eyes, the (mono) thiocarbamate herbicides do not appear to be highly toxic, but they do exacerbate chemical sensitivity. Extreme doses in laboratory animals do produce paralysis. There is a very remote possibility of “Antabuse” reactions from ethanol following extraordinary exposure to these (mono) thiocarbamates. They do not form ET on degradation.

Isoquinolinium-N-sulfonic acid thiocyanate/H₂O₂ as efficient reagent for thiocyanation of N-bearing (hetero)aromatic compounds

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Published in Journal of Sulfur Chemistry, 2021

Sobhan Rezayati, Fatemeh Kalantari, Ali Ramazani, Elham Ezzatzadeh

Moreover, this method is included in a direct method for the formation of C–S bonds, which is a very useful reaction in organic synthesis [9]. Thiocyanate compounds have an essential role in various areas of organosulfur chemistry which can be readily transformed into other functional groups such as thionitrile [10], aryl nitrile [11], thiocarbamate [12], sulfide [13], thiophenols [14], allyl sulfides [15], 5-sulfenyl tetrazoles [16], alkyl trifluoromethyl thioethers [17], disulfides [18], nitriles [19] and S-argio carbamothioate [20] (Scheme 2). Additionally, the products of thiocyanates and thiocyanation have been widely used as drugs, dyes and precursors for agrochemicals, as well as proved useful as intermediates in the synthesis of sulfur-containing heterocycles [21].

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Pesticides and Chronic Diseases

Isoquinolinium-N-sulfonic acid thiocyanate/H2O2 as efficient reagent for thiocyanation of N-bearing (hetero)aromatic compounds

Isoquinolinium-N-sulfonic acid thiocyanate/H₂O₂ as efficient reagent for thiocyanation of N-bearing (hetero)aromatic compounds