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Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Tannic acid exhibits anti-oxidant, anticancer, antimicrobial, and anti-mutagenic bioactivities, and these properties are exploited in Chinese traditional medicine. However, a report suggests that tannins from few food sources, such as betel nuts and herbal tea, cause cancer (Chung et al. 1998). However, tannic acids are effective against HIV, HSV, influenza virus, noro viruses, and papilloma viruses. Tannic acid inhibits viral replication by targeting multiple stages of viral infection (Kaczmarek 2020). It is reported to inhibit cancer cell viability by halting the cell cycle and induce apoptotic pathways majorly in small cell lung cancer (Nipin et al. 2020).
Herbs in Cancer Therapy
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Annum Malik, Shahzadi Sidra Saleem, Kifayat Ullah Shah, Learn-Han Lee, Bey Hing Goh, Tahir Mehmood Khan
Liver necrosis has been reported as a result of tannic acid use. Formation of intermediates possessing pro-oxidant activities and inhibition of functioning of antioxidant enzymes are the possible reported causes of this side effect (Chung et al. 1998).
Tissue engineering applications in breast cancer
Published in Journal of Medical Engineering & Technology, 2020
Mozaffar Mahmoodi, Shirin Ferdowsi, Somayeh Ebrahimi-Barough, Shaghayegh Kamian, Jafar Ai
In a study, Wu et al. [12] prepared self-assembling RADA16-I peptide hydrogel scaffold loaded with tamoxifen for breast reconstruction. The ADSCs isolated from liposuction were attached to the scaffold. The results suggested that this scaffold provide support for ADSCs cells attachment/proliferation and retain cytotoxic effect on MCF-7 cells, which might be a promising therapeutic breast tissue following lumpectomy. Schusterman et al. [13] reported a novel method of breast reconstruction using a 3D absorbable mesh scaffold and subsequent autologous fat grafting (AFG). Twenty-two patients underwent reconstruction and all patients were satisfied with final breast shape and size. Postoperative mammogram and magnetic resonance imaging revealed robust adipose tissue in the breast with a gradually resorbing mesh and no oil cysts or calcifications. Recently, Baldwin et al. [14] developed a novel tannic acid-collagen type I injectable bead scaffold material for breast reconstruction post lumpectomy in an in vivo rat model. Tannic acid is a polyphenol with anticancer and antibiotic properties. After 12 weeks, implants showed incorporation into native tissue with no fibrous encapsulation. Despite the presence of inflammatory cells in the remaining beads, fat tissue growth and collagen redistribution were observed within the beads over 12 weeks, showing incorporation within native subcutaneous tissue and indicating good biocompatibility and bioactivity of the implant.
Encapsulation of antioxidant compounds in biopolymer micelles
Published in Chemical Engineering Communications, 2020
Jolanta Pulit-Prociak, Małgorzata Kabat, Ewelina Węgrzyn, Michał Zielina, Marcin Banach
Tannic acid is an ester of gallic and digalic acids combined with glucose (Aguilar-Zárate et al. 2015). It occurs in bark, seeds, cones, and fruits of trees such as oak, mahogany, beech, and redwood. Tannic acid may also be found in galls that are formed on the leaves of beech and oak as a result of insect infiltration. Studies have shown that a solution of tannic acid at a concentration of 15 μg/cm3 is able to inhibit the lipid peroxidation of linoleic acid by 97.9%. It is also very effective to sweep away the DPPH radicals and chelate peroxidized metals, mainly in the form of Fe ions. Due to its very good antioxidant properties, it can be used as a preservative of both food and nutraceutics. It is also defined by its antibiotic, antibacterial, and antiviral characteristics (Gülçin et al. 2010). The solubility of tannic acid in various solvents is as follows: 2.86 g dissolves in 1 cm3 of water, 1 g dissolves in 1 cm3 of warm glycerol, and 0.1 g dissolves in 1 cm3 of ethyl alcohol. It is practically insoluble in chloroform, benzene and petroleum ether (PubChem Open Chemistry Database; Sigma Aldrich Product Information, St. Louis, MO).
Study to observe the applicability of the adsorption isotherms used for the adsorption of medicine organics onto activated carbon
Published in Particulate Science and Technology, 2018
Çiğdem Sarici-Özdemir, Yunus Önal
Naproxen sodium (NA), tannic acid (TA), and caffeine (CA) are product members of the pharmaceutical industry. Naproxen belongs to the arylacetic acid group of non-steroidal anti-inflammatory drugs, which can be used to treat diseases and to alleviate pain (Damiani, Bearzotti, and Cabezan 2002; Önal, Akmil-Başar, and Sarıcı-Özdemir 2007a). Caffeine is produced naturally in the leaves and seeds of many plants. It is classified as a drug based on its ability to stimulate the control nervous system, thus, causing enhanced levels of alertness. In addition, caffeine, being a xanthine derivative, possesses important pharmacological properties that have been exploited for application in industries as well as various pharmaceutical practices (Navarette-Casas and Garcia-Rodriguez 2006). Similarly, tannic acid has also been used in many applications and is utilized as a raw material in the production of several drugs. It is an anionic organic pollutant of relatively high molecular weight (average 1700 g · mol−1). In its deprotonated form tannic acid is a naturally occurring organic substance, which is churned out in the soil by the decomposition of organic matter. Tannic acid can create serious problems in the environment, since its nature becomes toxic as a water-soluble polyphenolic compound (Chang and Juang 2004; An and Dultz 2007).