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Self-Healing Polymers
Published in Asit Baran Samui, Smart Polymers, 2022
Self-healing hydrogels can be used over a long period with the desired functionality as they can maintain the integrity of network structures and mechanical properties. The approaches followed for self-healing are either dynamic covalent bonds or noncovalent bonds.
High strength PVA/poly (AACA-co-DMC) hydrogels self-healing in both alkali and acid solutions
Published in Journal of Dispersion Science and Technology, 2022
Siqi Wang, Xiaoyu Guo, Shuang Guan, Hai Fu, Xiufeng Wang, Peipei Guo
Self-healing hydrogels are a class of new materials which can repair themselves and restore the integrity when they are damaged.[1–5] This self-healing ability can greatly extend the service life and safety of the materials,[2,4,6,7] which is in line with the strategy of environmental protection and sustainable development. Generally, the self-healing process of hydrogel is mainly realized through the reversible physical interactions or the dynamic chemical bond.[4] In recent years, great progress has been made in the development of self-healing gels, and a variety of self-healing hydrogels based on H-bonds,[8–10] host–guest recognition function,[11,12] metal–ligand coordination,[13] hydrophobic interactions,[14,15] ionic bond,[16,17] boron ester bond[7] and other dynamic chemical bond[18] cross-linking are prepared.
Biocompatible conjugation for biodegradable hydrogels as drug and cell scaffolds
Published in Cogent Engineering, 2020
Self-healing hydrogels have the potential to broad pharmaceutical applications via the Schiff base reaction. The traditional hydrogels come across some challenges that will limit its application, such as suffering mechanical forces after injection that deform or even damage them. The key point to maintain both the structural and functional integrity is to give hydrogels the ability of self-healing (Burattini et al., 2010; Cong et al., 2013; Li et al., 2015; Y. Zhang et al., 2012). Different from traditional hydrogels, self-healing hydrogels possess a self-repair capability after damage and can be used as injectable materials (Cho & Ooya, 2018; Deng et al., 2012; Ding et al., 2015; Gaina et al., 2013; Pepels et al., 2013; Wei et al., 2016). Self-healing hydrogels could arrive at the spot and overcome fracture during the delivery during injection in vivo, then enhance the medicine delivery efficiency and improve the therapeutic effect. Herein, we put forward the Schiff base reaction to broaden the biopolymer-based self-healing hydrogel system for drug delivery and tissue engineering. The self-healing biopolymer hydrogel is presented by the crosslinking of aldehyde groups from oxidized alginate (OAlg) and amino groups from water-soluble carboxyethyl chitosan (CEC). The compressive and rheological tests exhibited that the composite hydrogels had good self-healing properties. Digital pictures were directly demonstrated the self-healing ability of hydrogels (Figure 7c). We prepared two identical hydrogels, used Rhodamine to stain one of them, put them together, and allowed them to self-heal at room temperature. After 2 h, the healed hydrogel was solid enough to overcome the stretching force from the outside and maintained the self-integrity undamaged matrix. The dynamic reversible covalent bonding made them lightly crosslink together, especially on the surface of the hydrogels, and resulted in the excellent self-healing ability.