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Herbs in Cancer Therapy
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Annum Malik, Shahzadi Sidra Saleem, Kifayat Ullah Shah, Learn-Han Lee, Bey Hing Goh, Tahir Mehmood Khan
Various strategies used to interfere with or prevent cancer progression or development are involved in chemoprevention. These strategies may use natural complexes or their synthetic analogs (Safarzadeh et al. 2014). One of the main activities of chemopreventive plants is to induce apoptosis in the malignant cells (Pal and Shukla 2003, Yang et al. 2013). In vivo studies of Saffron shows ability of inhibiting tumorigenesis through different mechanisms. Some of these mechanisms involve inhibition of RNA, DNA synthesis, free radical chain or topoisomerase II inhibition (Abdullaev, 2002). Curcumin inhibits cycloeskinase-2 production in epithelial colon cells and also induce apoptosis in cancer cells by blocking NF-kB signaling pathway. This blocking is caused by the control of IKB enzyme phosphorylation (Plummer et al. 1999, Ireson et al. 2002).
Nanoflower synthesis formed at different pH based on Crocus sativus L. (Croci stigma, saffron) extract and its major components: a new approach for enhancing antioxidant, antimicrobial and catalytic activities
Published in Inorganic and Nano-Metal Chemistry, 2023
Ayşe Baldemir Kılıç, Nilay Ildız, Sadi Yusufbeyoğlu, İsmail Öçsoy
Firstly, 120 mM CuSO4 stock solution was freshly prepared in distilled water. CuSO4 solution (0.08 millimolar, mM) was added to phosphate buffer (PBS) (10 mM, pH: 5, 7.4, 9) and an addition of 0.02 mg/mL of saffron extract, safranal, and crocin was followed. The resulting mixture was vortexed rapidly for about 30 s to provide a homogeneous reaction between organic and inorganic components. Each mixture was then left for incubation for 72 h without interfering. Right after incubation, the reaction was stopped by centrifuging the mixture, and the blue-colored precipitable-coloreddication of saffron nanoflower (saffron Nf), crocin nanoflower (crocin Nf) and safranal nanoflower (safranal Nf) were collected.[4,12] The precipitates like Nfs were dried, characterized, and stored for further use. The formation of the Nf was illustrated in Figure 1.