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Innovation and Challenges in the Development of Functional and Medicinal Beverages
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Natural Products Pharmacology and Phytochemicals for Health Care, 2021
Dayang Norulfairuz Abang Zaidel, Ida Idayu Muhamad, Zanariah Hashim, Yanti Maslina Mohd Jusoh, Eraricar Salleh
Another type of vitamin B is Vitamin B6. This vitamin’s activity is shown by pyridoxine which consists of three different compounds that are pyridoxol, pyridoxal, and pyridoxamine. Generally, Vitamin B is essential energy production by helping in converting food into energy and helps in maintaining the brain function. Vitamin B is important in neurologic and for various nervous system functions, and it also helps to produce an essential protein [33].
Fermentative Production of Vitamin B6
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2020
Jonathan Rosenberg, Björn Richts, Fabian M. Commichau
Vitamin B6 has been discovered almost one century ago and is an essential organic micronutrient for organisms from all kingdoms of life (György, 1956; Hellmann and Mooney, 2010; Kraemer et al., 2012; Eggersdorfer et al., 2012). Vitamin B6 collectively designates the water-soluble vitamers pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM), and their respective phosphate esters pyridoxal 5′-phosphate (PLP), pyridoxine 5′-phosphate (PNP), and pyridoxamine 5′-phosphate (PMP) (Fig. 1.1A; Rosenberg, 2012; Rosenberg et al., 2017). PLP is the most important vitamer serving as a cofactor for a plethora of proteins and enzymes (Mehta et al., 1993; Jansonius, 1998; Mehta and Christen, 2000; Christen and Mehta, 2001; Eliot and Kirsch, 2004; Phillips, 2015). Estimations revealed that over 160 enzymes with distinct catalytic activities require vitamin B6 as a cofactor (about 4% of all described catalytic activities) (Percudani and Peracchi, 2009). Most of the PLP-dependent enzymes are involved in biosynthesis of amino acids, decarboxylation and racemization reactions, cleavage of Cα-Cβ bonds, α-, β- and γ-elimination or replacement reactions (John, 1995; Mehta and Christen, 2000; Christen and Mehta, 2001; Eliot and Kirsch, 2004). Moreover, PMP serves as a cofactor for enzymes of deoxysugar biosynthetic pathways (Burns et al., 1996; Romo and Liu, 2011). Furthermore, PLP modulates the activity of DNA-binding transcription factors in eukaryotes and prokaryotes (Oka et al., 2001; Huq et al., 2007; El Qaidi et al., 2013; Belitsky, 2004a; Belitsky, 2014; Tramonti et al., 2015, 2017 2018; Suvorova and Rodionov, 2016; Tramonti et al., 2017). The finding that about 1.5% of the genes of many free-living prokaryotes code for PLP-dependent proteins underlines the importance of the B6 vitamer for the function of proteins and catalytic enzymes (Percudani and Peracchi, 2003). There is also evidence that vitamin B6 is implicated in oxidative stress responses in plants (Bilski et al., 2000; Mooney and Hellmann, 2010; Moccand et al., 2014; Vanderschuren et al., 2013). Thus, vitamin B6 fulfils a variety of vital functions in different cellular processes (Fitzpatrick et al., 2007; Mooney et al., 2009; Vanderschuren et al., 2013; Parra et al., 2018).
Engineered production of pyridoxal 5′-phosphate in Escherichia coli BL21
Published in Preparative Biochemistry & Biotechnology, 2022
Min He, Jian Ma, Qingwei Chen, Qili Zhang, Ping Yu
Vitamin B6 is a general name of a class of 2-methyl-3-hydroxyl-pyridine compounds, which exist in the form of phosphate in organisms. There are six convertible pyridine derivatives of vitamin B6, which contain pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5′-phosphate (PNP), pyridoxamine 5′-phosphate (PMP), and pyridoxal 5′-phosphate (PLP).[1]