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Macrocyclic Receptors Synthesis, History, Binding Mechanism: An Update on Current Status
Published in Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney, Macrocyclic Receptors for Environmental and Biosensing Applications, 2022
Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney
Pillararenes can be synthesized using a single monomer unit known as homo-cyclooligomerization (Yang et al. 2016 a). In 2008, homo-cyclooligomerization was used for the synthesis of the first symmetrical 1,4-dimethoxypillar[5]arene from the easily available precursors such as 1,4-dimethoxybenzene, paraformaldehyde, and boron trifluoride etherate (Scheme 35).
Cation-mediated sandwich formation between benzene and pillar[5]arene: a DFT study
Published in Molecular Physics, 2019
Nabajit Sharmah, Pradip Kr. Bhattacharyya
In summary, the study conclusively asserts the feasibility of cation–π complexes as well as sandwiches between pillar[5]arene and benzene moiety via alkali metal ions. Result confirms that due to the interaction of alkali metal ion with the pillar[5]arene slight deformation in the normal symmetrical structure of pillar[5]arene is observed. Interaction energies of the complexes are found to depend on size, position and number of metal ions. Interaction energy is higher for the complexes with the metal ion present inside the cavity than the complex with the metal ion outside the pillar[5]arene. Interaction energies suggest the formation of stable sandwiches which might be important from chemistry viewpoint. TDDFT study advocates that the absorption spectra of Pi–nM complexes shifted during sandwich formation. Pillararene-based molecular recognition and self-assembly have turn out to be more attractive on account of their extensive use in drug delivery, sensing, catalysis, etc. This work might be important for the efficient and selective adsorption and release of multifunctional drug molecules. In addition, the study also indicates the possibility of the pillar[5]arene moieties to interact with different metal ions present in the environment and the biological systems via cation–π interaction.