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Compounds of Plant Origin as AMP-Activated Protein Kinase Activators
Published in Alexander V. Kutchin, Lyudmila N. Shishkina, Larissa I. Weisfeld, Gennady E. Zaikov, Ilya N. Kurochkin, Alexander N. Goloshchapov, Chemistry and Technology of Plant Substances, 2017
Daria S. Novikova, Gleb S. Ivanov, Alexander V. Garabadzhiu, Viacheslav G. Tribulovich
Anticancer activity is typical for many plant stilbenes [56]. Piceatannol (Fig. 9.7), found in mycorrhizal and nonmycorrhizal roots of Norway spruces (Picea abies) and also in red wine, can be noted among them. It was shown that its antiproliferative activity is mediated by cell cycle arrest at low concentrations and apoptosis induction at high concentrations [57]. Recently, a hypoglycemic effect of piceatannol was revealed. It was found that piceatannol improves glucose uptake in myocytes through the phosphorylation of AMPK and translocation of GLUT4 (glucose transporter 4) to the plasma membrane, as well as prevents an increase in blood glucose levels at early stages and improves the impaired glucose tolerance at late stages of diabetes in diabetic mouse models. The ability of piceatannol to stimulate the activation of AMPK, GLUT4 translocation, and glucose uptake in muscle cells in the absence of insulin determines the possibility for this compound to overcome the insulin resistance, which makes it a promising candidate for the prevention and treatment of diabetes [58].
Sodium-glucose transporter (SGLT2) inhibition: A potential target for treatment of type-2 Diabetes Mellitus with Natural and Synthetic compounds
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Shubham Batra, Prabhjeet Kaur Bamrah, Manjusha Choudhary
The widespread growth of a Gnetum gnemonoides species can be found across Southeast Asia and the Pacific, including New Guinea, Malaysia, the Philippines, and Indonesia. It is reported to contain stilbenoids, which exhibit biological qualities as antibacterial, antioxidant, hepatoprotective, and enzyme inhibitory action. Bronchitis, asthma, and arthritis have all been treated with this species as a kind of traditional medicine [68]. Gnetum gnemonoides include several stilbenoids that have been isolated, resveratrol, oxyresveratrol, piceatannol, and isorhapontigenin have been shown SGLT inhibitory activity. Gneyulins A and B, two stilbene trimmers made up of oxyresveratrol constituent units, demonstrated modest inhibitory activity against SGLT1 and SGLT2, whereas Noidesols A and B, two dihydroflavonol-C-glucosides, had no SGLT inhibitory potential [12].