Macrocyclic ligand

A macrocyclic ligand is a type of ligand system that possesses a central ligand cavity, enhanced stabilities of macrocyclic complexes, well-defined spatial attributes, and in some cases, unusual redox properties. These properties make them useful design elements for constructing metallo-supramolecular systems. Macrocyclic ligand carriers, such as crown ethers, are also used for the separation of alkali, alkaline earth metals, and trivalent lanthanides.From: Macrocyclic Receptors for Environmental and Biosensing Applications [2022], Membrane Technologies and Applications [2019]

Macrocyclic Receptors for Biomolecules and Biochemical Sensing

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Published in Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney, Macrocyclic Receptors for Environmental and Biosensing Applications, 2022

Satish Kumar, Priya Ranjan Sahoo, Violet Rajeshwari Macwan, Jaspreet Kaur, Mukesh, Rachana Sahney

Many pharmacological objectives such as detection, solubilization in aqueous systems, enhanced transport and targeted delivery can be achieved in the future by the development of macrocyclic ligand as host molecules for various lipids as guests.

One-pot synthesis and characterization of Schiff base macrocyclic complexes as a potential bioactive core – a review

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Published in Journal of Coordination Chemistry, 2021

J. P. Remiya, T. S. Sikha, B. Shyni

Metal complexes of Schiff base macrocycles can be synthesized by the required metal salts reacting with preformed macrocyclic Schiff base ligand under specific conditions, but there are potential drawbacks in this strategy. Therefore, the best method for development of macrocyclic Schiff base complexes includes one-pot cyclization reactions where the metal ion increases the yield of the macrocyclic product [70]. The metal ions and the anions are vital as the equilibrium among the size of the anion and cation will direct the dissociation of the salt of metal in the reaction medium [79]. The metal ions act as a template for the ligand framework to take suitable geometry [80]. Through the metal template effect, synthesis of multidentate macrocyclic ligand has been archived in significant yields [8, 38]. Macrocyclization can help to make better oral absorption, pharmacological activity, cell permeability and metabolic stability for drug candidates [81].

Macrocyclic ligand

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Macrocyclic Receptors for Biomolecules and Biochemical Sensing

One-pot synthesis and characterization of Schiff base macrocyclic complexes as a potential bioactive core – a review