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Medicinal Mushrooms
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Temitope A. Oyedepo, Adetoun E. Morakinyo
Lentinan (also known as Shiitake) is a water-soluble polysaccharide that is extracted from the fruiting body of Lentinula edodes which has been documented to have antitumor activities and proven to potentiate human immunity (Tanigawa et al., 2016). Its chemical formula is C42H72O36 (Figure 7.1) with a molecular weight of 400,000−1,000,000 daltons (Ngai and Ng, 2003). It is a common BRM which has been approved for use as an adjuvant for cancer treatments in several countries (Ngai and Ng, 2003). The bioactive ingredient of lentinan is β-1, 3-D-glucan polymer with β-1, 6 or β-1, 4 branches. The oral bioavailability of Lentinan is reportedly limited so its administration is usually by parental injection even though it is sometimes taken orally as nutritional products.
Polysaccharides
Published in Stanislaw Penczek, H. R. Kricheldorf, A. Le Borgne, N. Spassky, T. Uryu, P. Klosinski, Models of Biopolymers by Ring-Opening Polymerization, 2018
Lentinan, which is isolated from a Japanese edible mushroom, Lentinus edodes (Berk.), is an immunomodulator that exerts its inhibitory action not only on allogeneic tumors but also on syngeneic and autologous tumors.131 Lentinan has been sold as a drug for some kinds of cancers in Japan since 1985, The primary structure of lentinan is a (1—>3)-|3-glucan having two β-1,6-glucopyranoside branchings for every five β-1,3-glucopyranoside backbone linkages. In addition, it is known that the fruit bodies of Dictyophora indusiata Fisch include a partially acetylated linear (1→3)-α-d-mannan132 that exerts antitumor and antiinflammatory activities. Thus, in order to synthesize such biologically active polysaccharides, the ring-opening polymerization of 1,3-anhydro sugars has been studied.
Changes in the morphometric, textural, and aromatic characteristics of shiitake mushrooms during combined humid-convective drying
Published in Drying Technology, 2021
Shankar Subramaniam, Xin-Yao Wen, Zhen-Tao Zhang, Pu Jing
Shiitake mushrooms (Lentinus edodes), better known in China as Xiang-gu, have been used by people for thousands of years as food or medicine. Some of the major bioactive compounds in shiitake have anti-tumor and anti-hypertensive properties.[1] One of the major compounds is lentinan (a glucan) and another is vitamin D (from ergosterol), which together elicit a good immune response in humans.[2,3] Lentinan is a high-molecular weight polysaccharide of approximately 500 kDa and is found in the cell walls of shiitake mushrooms.[4]
Industrial production and applications of α/β linear and branched glucans
Published in Indian Chemical Engineer, 2021
Geetha Venkatachalam, Senthilkumar Arumugam, Mukesh Doble
The most efficient way for the isolation of water-soluble fungal glucan is hot or boiling water extraction. Lentinan is isolated from common edible mushroom Lentinus edodes which are β-(1,3) linked in the backbone with β-(1,6) branches. Lentinan is extracted by ethanol factional precipitation, solubilisation by acetic acid followed by chromatographic column purification [30].