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Terpenoids in Treatment of Liver Disease
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Akash Prasad, Kaustav Dutta Chowdhury
Kahweol is a diterpene molecule, found in the beans of Coffea arabica. It has significantly reduced transforming growth factor (TGF)-β–stimulated collagen type I and connective tissue growth factor (CTGF) expression in Lieming Xu-2 (LX2), human hepatic stellate cell line, primary hepatocytes and α-mouse liver 12 (AML12) cells (an immortalized mouse hepatocyte). It has also decreased TGF-β–stimulated phospho-signal transducer and activator of transcription-3 (STAT3) expression in AML12 cells and primary hepatocytes but not in LX2 cells (Shi et al. 2013).
Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid
Published in Journal of Toxicology and Environmental Health, Part A, 2018
Jacqueline Morais Alves, Luís Fernando Leandro, Juliana Marques Senedese, Pâmela Tinti de Castro, Daiane Eleutério Pereira, Flávia Aparecida Resende, Débora Leite Campos, Jonas Joaquim Mangabeira da Silva, Eliana Aparecida Varanda, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio, Denise Crispim Tavares
There are few apparent studies available regarding CA, and this is the first to investigate its antigenotoxic potential using in vivo and in vitro assays. However, a number of investigators evaluated the protective effects of other diterpenes. Cavin et al. (2001) demonstrated the antigenotoxic properties of the coffee diterpenes, cafestol, and kahweol, against AFB1 genotoxicity in rat and human cells. These coffee diterpenoids also exhibited protective effects against carcinogens present in the human diet in human-derived hepatoma (HepG2) cells (Majer et al. 2005). In both cases, the antigenotoxic effects were attributed to inhibition of activating enzymes (cytochrome P450; sulfotransferase) and to induction of detoxifying enzymes. Nicolella et al. (2014) noted that manool, a labdane-type diterpene like CA, exerted a protective effect against chromosome damage induced by MMS in HepG2 cells, but not V79 cells. The differential effect of manool in V79 and HepG2 cells may be due, at least in part, to its ability to induce drug-metabolizing enzymes that are present to some extent in HepG2 cells (Nicolella et al. 2014).