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Plant Product-Based Nanomedicine for Malignancies: Types and Therapeutic Effects
Published in Khalid Rehman Hakeem, Majid Kamli, Jamal S. M. Sabir, Hesham F. Alharby, Diverse Applications of Nanotechnology in the Biological Sciences, 2022
Zuha Imtiyaz, Tabish Mehraj, Andleeb Khan, Mir Tahir Maqbool, Rukhsana Akhter, Mufeed Imtiyaz, Wajhul Qamar, Azher Arafah, Muneeb U. Rehman
Resveratrol and curcumin are widely known and studied phytochemicals, they have been extensively explored for their anticancer properties. However, their poor bioavailability, selectivity, and absorption are the shortcoming limiting their clinical applications. Therefore, human epidermal growth factor receptor (HER)2-targetted immune-liposomes coupled with trastuzumab were used to carry drugs (resveratrol and curcumin), and they displayed exemplary antiproliferative effect in two breast cancer cell lines, MCF7 and JIMT1 (Catania et al., 2013). Liposomal curcumin was also found effective in two prostate cancer cell lines wherein it was able to inhibit the proliferation of two prostate cancer cell lines, LNCaP and C4-2B (Thangapazham et al., 2008). Artemisinin is a famous phytochemical known for its antimalarial effect, and recent studies have reported its anticancer property. In order to develop new carrier strategies for better delivery and activation inside the cancer tissue, it was loaded with transferrin-conjugated liposomes. Results showed that conjugation of transferrin resulted in better delivery of artemisinin and also it was observed the cytotoxic effect of artemisinin on colon cancer cells, HCT8 (Leto et al., 2016). Honokiol, one more anticancer phytochemical that was formulated into PEGylated liposomal honokiol to have better solubility also enhanced its anticancer effect (Wang et al., 2011).
Polyphenol Nanoformulations for Cancer Therapy: Role of Milk Components
Published in Lohith Kumar Dasarahally-Huligowda, Megh R. Goyal, Hafiz Ansar Rasul Suleria, Nanotechnology Applications in Dairy Science, 2019
Lignans are found in dietary fibers. It has numerous therapeutic activities including anti-inflammatory and antioxidant properties. Honokiol (3′,5-di(2-propenyl)-1,1′-biphenyl-2,4′-diol, a lignan), a constituent of the Chinese medicinal plant Magnolia officinalis L. (Magnoliaceae), has plenty of pharmacological effects such as antithrombotic, anti-inflammatory, anti-rheumatic, and antioxidant with anxiolytic, central nervous system (CNS) depressant and muscle relaxant activities. It also has a strong antitumor activity. However, the hydrophobic (water repelling) properties restrict its vascular administration. Nanoformulation of honokiol showed anticancer effects in the mouse Lewis lung cancer LL/2 cell lines via G0/G1 cell cycle arrest.95
Ballpoint tip-protected oil-in-salt liquid-phase microextraction with high performance liquid chromatography for the determination of magnolol and honokiol from cortex Magnoliae officinalis
Published in Instrumentation Science & Technology, 2020
Run-Qin Wang, Xin Ge, Xuan Chen, Shuang Hu, Li Yang, Dan Li, Xiao-hong Bai
In this work, ballpoint tip-protected oil-in-salt liquid-phase microextraction (BT-OIS-LPME) was proposed and introduced for extraction and preconcentration of trace levels of magnolol and honokiol in cortex Magnoliae officinalis prior to analysis by high-performance liquid chromatography (HPLC) with ultraviolet detection. The experimental variables affecting the extraction performance were studied and optimized in detail. The relationship of enrichment factor and extraction efficiency in BT-OIS-LPME was determined. The enrichment factors for magnolol and honokiol were evaluated along with their extraction efficiencies. Two procedures, salt covered on the organic solvent and added in the sample phase, were compared and discussed. In addition, the proposed BT-OIS-LPME protocol was compared with other microextraction methods for the isolation and enrichment of magnolol and honokiol from complex matrices reported in the literature.