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Structures
Published in Thomas M. Nordlund, Peter M. Hoffmann, Quantitative Understanding of Biosystems, 2019
Thomas M. Nordlund, Peter M. Hoffmann
Heme is a prosthetic group, a group at the center of activity, of proteins and enzymes (see Figure 5.8). The molecular mass of heme is between 600 and 700 Da, depending on the particular heme. Proteins with heme prosthetic groups are called hemoproteins or heme proteins. Hemoproteins have biological functions including the transport of O2, chemical catalysis, diatomic gas detection, and electron transfer. The heme iron serves as a source or sink of electrons during electron transfer or redox (oxidation–reduction) chemistry, and as a binding site for molecules such as O2 (good) and CO (not good). Hemoproteins achieve their variety of functions by modifying the environment of the heme, sometimes forming covalent bonds to groups on the edge of the heme or providing a different charge or dielectric environment. We now note a few obvious features of the heme group, leaving the details for later.
Recent Advances in Artificial Cells With Emphasis on Biotechnological and Medical Approaches Based on Microencapsulation
Published in Max Donbrow, Microcapsules and Nanoparticles in Medicine and Pharmacy, 2020
Heme is one of the components of hemoglobin. Tsuchida (in Japan) is carrying out exciting research on preparing synthetic heme for the transport of oxygen12 (Table 2). He incorporated synthetic heme into lipid membrane artificial cells. The results of animal studies are very promising.
Analysis of porphyrin, PETIM and zinc porphyrin dendrimers by atom-bond sum-connectivity index for drug delivery
Published in Molecular Physics, 2023
Rong-Rong Huang, Sahar Aftab, Sadia Noureen, Adnan Aslam
Dendrimers for drug delivery are employed using a nanoconstruct approach. They have evolved into an important class of nanostructured carriers for the progress of nanomedicine in the treatment of a wide range of disorders. Because of their structural diversity and versatility, bacteria have been employed to deliver medications and genes in a number of ways. Porphyrin is required for haemoglobin to function. Heme is a protein found in red blood cells that links to porphyrin, binds iron, and delivers oxygen from the pulmonary system to the body's other organs. To put it another way, our bodies employ porphyrin to create haemoglobin. It is used in the treatment of porphyria (which refers to a category of disorders caused by an increase in the natural chemicals in the body that produce replete porphyrin). To limit the body's natural formation of porphyrin, it is medicated with an ‘injection of hemin’, a heme-like medication.