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Medical Applications for 3D Printing
Published in Yoseph Bar-Cohen, Advances in Manufacturing and Processing of Materials and Structures, 2018
David K. Mills, Karthik Tappa, Uday Jammalamadaka, Patrick A.S. Mills, Jonathan S. Alexander, Jeffery A. Weisman
Among the biodegradable synthetic polymers that offer significant potential for customization is PCL, a semicrystalline polymer that exhibits good mechanical properties, has a low melting point (55°C), and is both biocompatible and biodegradable (Hollister, 2005; Schantz et al., 2005; Wang et al., 2007). It is formed by the ring opening polymerization process of ε-caprolactone. In the body, PCL degrades in two phases. It first undergoes hydrolysis of ester bonds and forms fragments of caprolactone oligomers. These oligomers are then engulfed by macrophages, and they undergo degradation inside phagosomes by lysozyme enzymes (Barrows, 1986). Since this polymer exhibits low mechanical strength, its use in implant technology is limited to non-load-bearing regions exclusively.
Biodegradable Polymers as Drug Carrier Systems
Published in Severian Dumitriu, Valentin Popa, Polymeric Biomaterials, 2020
Biocompatibility and toxicology of poly(caprolactone), which was synthesized using Ti(OBu)4 as an initiator, were determined (Chen et al. 2000). The results obtained showed that poly(caprolactone) films have a mild inflammatory reaction in the early days of planting and after 3 months the inflammation disappeared. They conclude that poly(caprolactone) material possesses good biocompatibility and has a good developmental prospect.
Microplastic and Nanoplastic Pollution in Water Bodies from Conventional Packaging Materials
Published in Arbind Prasad, Ashwani Kumar, Kishor Kumar, Biodegradable Composites for Packaging Applications, 2023
PCL obtained from polymerization of ε-caprolactone has a low melting point and low viscosity. It has the advantages of biodegradability and high thermal processability, but has poor stress fracture resistance, barrier properties, dyeability and adhesion, which limits its usage in packaging sector. This limitation can be overcome by blending it with other polymers such as PLA and cellulose-based polymers [25].
Physicochemical and biological properties of nanohydroxyapatite grafted with star-shaped poly(ε-caprolactone)
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Eleni Cristina Kairalla, José Carlos Bressiani, Ana Helena de Almeida Bressiani, Maria Tereza de Carvalho Pinto Ribela, Olga Zazuco Higa, Alvaro Antonio Alencar de Queiroz
It is already widespread in the literature that poly(ε-caprolactone) (PCL) is one of the most attractive and promising synthetic polymers for applications in regenerative medicine due to their biodegradability, FDA approval and thus, it has potential importance in several different applications in medicine [22, 23].