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Clinical Effects of Pollution
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 5, 2017
William J. Rea, Kalpana D. Patel
CP enzymes are essential for detoxification of many compounds in the liver973 which have to do with the onset or aggravation of CS. In fact when these toxic hydrocarbons are inhaled as a part of heavy traffic or other sources, they exacerbate the CS and at times may even cause the CS. Intraperitoneal exposure of rats to Roundup in acute doses over a short time interval induced irreversible damage to hepatocytes and elevated urinary markers of kidney disease. This was associated with lipid peroxidation and elevated levels of the inflammatory cytokine TNF-α.974 CYP3A is constitutively expressed in human intestinal villi and plays an important role in drug metabolism.975 This may be why chemically sensitive patients are so intolerant of most medications used for any prescription. Celiac disease is associated with a decrease in the intestinal CYP3A.976 This defect is restored by a gluten-free diet. This decrease in CYP found in the chemically sensitive also results in a failure of detoxification of many chemicals.
A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering approaches for pharmaceutical technologies
Published in Drying Technology, 2021
Sagar Pardeshi, Mahesh More, Pritam Patil, Chandrakantsing Pardeshi, Prashant Deshmukh, Arun Mujumdar, Jitendra Naik
GI epithelium contains a large number of enzyme and transporter systems with regional variation across its length. These can be active or passive result in influx or efflux of the API. The most well-known enzyme cytochrome P450 isoforms (CYP3A) is responsible for drug metabolism which can be found in the highest concentration in the duodenum. Inter-subject variability due to genetic polymorphism and need to consider while estimating preclinical pharmacokinetic data and can have a profound effect on bioavailability.[137]