interstitial cells of Cajal

Interstitial cells of Cajal (ICC) are specialized cells found in the gastrointestinal tract that regulate the motility of smooth muscle by initiating slow waves in both longitudinal and circular muscle layers. They are also important sites for the reception of neurotransmitters. ICC generate an electrophysiological activity called GI slow-wave, which is essential for the regulation of digestion. ICC work in conjunction with smooth muscle cells to generate this activity.From: Biomedical Engineering Fundamentals [2019], Recent progress in electrophysiology and motility mapping of the gastrointestinal tract using multi-channel devices [2020], Tissue Engineering [2019]

Membrane Models

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Published in Joseph D. Bronzino, Donald R. Peterson, Biomedical Engineering Fundamentals, 2019

Anthony Varghese

Interstitial Cells of Cajal Interstitial cells of Cajal are pacemaking cells in the gastrointestinal tract. e model of Youm et al. (2006) includes voltage-dependent sodium, potassium, and calcium currents, an Na-K pump, an Na-Ca exchanger, and a plasmalemmal calcium pump; it also has equations for cytosolic calcium changes. A newer model by Faville et al. (2009) includes a T-type calcium current as well as mitochondrial calcium handling and ER calcium release.

Systematic review on gastric electrical stimulation in obesity treatment

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Published in Expert Review of Medical Devices, 2019

Alimujiang Maisiyiti, Jiande Dz Chen

GES is, however, different from other neuromodulation methods. When an electrical stimulus is applied to the seromuscular layer of the gastric wall, it interacts with the intrinsic enteric nerves, the extrinsic autonomic nerve, the interstitial cells of Cajal and the smooth muscle. Their combined responses to the stimulation determine the final outcomes. Therefore, stimulation parameters have been carefully selected in order to achieve expected outcome. Moreover, the stomach has its own electrical rhythm and this must be also taken into consideration whether the stimulation should be designed to enhance or disrupt this intrinsic electrical activity.

interstitial cells of Cajal

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Systematic review on gastric electrical stimulation in obesity treatment