Synteny

Synteny

Synteny refers to the arrangement of two or more loci on the same chromosome, regardless of their physical distance from each other. It is often used in genomic research to identify genes of interest by comparing the synteny of related species. The high degree of genomic synteny between species, such as zebrafish and humans, allows for the study of analogous expression of proteins involved in human disease.From: Scientific and Technical Terms in Bioengineering and Biological Engineering [2018], Medical Biotechnology, Biopharmaceutics, Forensic Science and Bioinformatics [2022], Zebrafish irritant responses to wildland fire-related biomass smoke are influenced by fuel type, combustion phase, and byproduct chemistry [2021]

Bioinformatics

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Published in Hajiya Mairo Inuwa, Ifeoma Maureen Ezeonu, Charles Oluwaseun Adetunji, Emmanuel Olufemi Ekundayo, Abubakar Gidado, Abdulrazak B. Ibrahim, Benjamin Ewa Ubi, Medical Biotechnology, Biopharmaceutics, Forensic Science and Bioinformatics, 2022

O. M. Oyawoye, H. A. Olorunsola, A. O. Oluduro, O. O. Bamigboye, E. K. Oladipo, T. M. Olotu, I. J. Adeosun, M. O. Kaka, O. O. Obembe

Comparing genome organization across cell types and species may reveal important details about the processes that underpin these genomic structures, such as their biochemical pathways (Potgieter et al., 2020). To identify the genes of interest, syntenic regions of related species considered to house a gene of known role were used at the genome structural stage. The mechanism between various species has proven to be such a powerful tool that databases have been created to capitalize on. C-InterSecture is a bioinformatics tool that was recently developed and used to identify regions that alter their spatial organization during vertebrate evolution.

Genetics of congenital cataract, its diagnosis and therapeutics

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Published in Egyptian Journal of Basic and Applied Sciences, 2018

Luqman Khan, Nargis Shaheen, Qaisar Hanif, Shah Fahad, Muhammad Usman

The gene for the MP19 was linked to human chromosome number 19. Mapping the L1M2 gene to mouse chromosome number 7 in an area of reserved synteny with human chromosome number 19 [22]. Another research identified an innate Iraqi Jewish family of autosomal recessive manner with a late pulverulent cortical cataract at 19q. Sequencing of LIM2 gene discovered a homozygous T-to-G change, and this declared to be the first report of cataract development in humans associated with a mutation in LIM2.

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Bioinformatics

Genetics of congenital cataract, its diagnosis and therapeutics