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Microfluidic Platforms for Wound Healing Analysis
Published in Raju Khan, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, A. B. P. Mishra, Advanced Microfluidics-Based Point-of-Care Diagnostics, 2022
Lynda Velutheril Thomas, Priyadarsini Sreenivasan
Iron, which is another cofactor required for collagen synthesis, moderates the immune response during inflammation. This is elucidated by the prolongation effect on inflammation as is seen in cases of iron deficiency. However, there are no proven studies about the effects of this factor, suggesting that iron supplementation alone would improve wound healing in the absence of a severe deficiency in the host. Lu et al. (2017) demonstrated a rapid diagnostic test and mobile-enabled platform for simultaneously quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive protein) status. Yap et al. (2018) reviewed the potential microfluidics applications in the field of nutrition, specifically to diagnose iron deficiency anemia (IDA) detection. Li et al. (2013) discussed the potential chances for microfluidics in the field of nutrition in their review and highlighted some of the recent advances in microfluidics blood analysis systems that have the capacity to detect biomarkers of nutrition.
Exposure and Health Surveillance in Gulf War Veterans Exposed to Depleted Uranium
Published in Alexandra C. Miller, Depleted Uranium, 2006
Katherine S. Squibb, Melissa A. McDiarmid
Changes in other serum and urine parameters also have shown no pattern of progressive changes except for a consistent, though nonsignificant, increase in the urinary excretion of the low molecular weight retinol-binding protein (RBP) since 2001. This could be an indication of early changes in renal proximal tubule function. These results have been accompanied by inconsistent changes in total urine protein, however, and no differences have been observed in beta2-microglobulin or two other markers of renal cell damage, NAG and IAP. RBP excretion will continue to be carefully monitored, based on work by Squibb et al. [17], which reports that predicted renal concentrations of U in the DU-exposed soldiers excreting the highest concentrations of U are likely to have already accumulated U in their kidneys to concentrations approaching 1 ppm. Although a critical threshold of 3 ppm was established for workers in U industries in 1960 by the ICRP [31], more recent work suggests that a 10-fold lower concentration (0.3 ppm) may be more protective [10,32,33].
Effects of Whole Body Vibration in Adult Individuals with Metabolic Syndrome
Published in Redha Taiar, Christiano Bittencourt Machado, Xavier Chiementin, Mario Bernardo-Filho, Whole Body Vibrations, 2019
D. da Cunha de Sá-Caputo, M. Fritsch Neves, Mario Bernardo-Filho
Oda (2012) pointed out that high energy fast-food environment, sedentary life style, and other obesogenic socioeconomic environment factors have contributed to an obesity pandemic in the developed world. Moreover, genetic predisposition to obesity and proinflammatory reactions would be also associated with the MetS. As the adipose tissue secretes humoral substances, such as tumor necrosis factor-a (TNF-a), leptin, adiponectin, resistin, visfatin, monocyte chemoattractant protein-1, retinol binding protein-4, and adipocyte-type fatty acid binding protein, obesity has been considered as an endocrine and inflammatory disorder related with IR rather than anthropometric fatness.
Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress
Published in Journal of Toxicology and Environmental Health, Part B, 2021
Jae Hyeon Park, Byung Mu Lee, Hyung Sik Kim
The major features of Cd-induced nephrotoxicity are proteinuria, aminoaciduria, glucosuria, and phosphaturia. Initial urinary biomarkers of Cd-induced renal damage include low-molecular-weight proteins such as β2-microglobulin, retinol binding protein (RBP), and enzymes such as N-acetyl-β-D-glucosaminidase. RBP is the most specific marker of proximal tubular dysfunction (Vaidya, Ferguson, and Bonventre 2008). Long-term exposure to Cd produces glomerular damage and albuminuria, resulting in the development of end-stage renal failure (García and Arceo 2018; Ginsberg 2012; Schnaper 2014). Notably, patients with diabetes are more likely to experience renal tubular damage following Cd toxicity than those without (Satarug, Vesey, and Gobe 2017). Fanconi syndrome is a rare medical condition involving impairment in protein, amino acid, glucose, bicarbonate, and phosphate reabsorption following Cd-induced oxidative stress, resulting in the apoptosis of tubular cells (Haque, Ariceta, and Batlle 2012).
Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli
Published in Preparative Biochemistry and Biotechnology, 2019
Herng C. Leow, Katja Fischer, Yee C. Leow, Katleen Braet, Qin Cheng, James McCarthy
The periplasmic disulfide oxidoreductase A protein (DsbA) belongs to the thioredoxin protein superfamily and is responsible for disulfide bond formation and rearrangement in E. coli.[34,35] DsbA, otherwise, in combination with other Dsb peptide family has been widely used to produce functional recombinant proteins in biomedical research. For instances, the performance and yield of functional scFv,[36] horseradish peroxidase,[37] human plasma retinol-binding protein,[38] nerve growth factor beta,[39] and brain-derived neurotrophic factor[40] have been improved using this fusion approach.
The association between retinol-binding protein 4 and risk of type 2 diabetes: A systematic review and meta-analysis
Published in International Journal of Environmental Health Research, 2023
Xiaomeng Tan, Han Zhang, Limin Liu, Zengli Yu, Xinxin Liu, Lingling Cui, Yao Chen, Huanhuan Zhang, Zhan Gao, Zijian Zhao
A comprehensive literature research was performed using MEDLINE and EMBASE until 3 December 2022. The following key terms were used: “type 2 diabetes” or “T2DM” and “RBP4” or “retinol-binding protein 4” or “retinol-binding protein”. Specific search strategies are provided in the supplementary materials. The reference lists of relevant review articles were also scanned to identify more potential related researches. Two investigators independently reviewed all identified studies (Xm T and HZ). Any differences were resolved by a senior author (Xx L).