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History of the Frank Reidy Research Center for Bioelectrics
Published in Marko S. Markov, James T. Ryaby, Erik I. Waldorff, Pulsed Electromagnetic Fields for Clinical Applications, 2020
The first study demonstrating effects of electroporation in humans, called bleomycin-mediated electrochemotherapy (ECT), was carried out by this group (Glass et al., 1996a). Electroporation was applied after systemic administration of the drug in two patients with basal cell carcinoma. Partial and complete responses were seen in lesions without significant side effects. Heller’s group also showed efficacy with ECT after intralesional delivery of bleomycin in five patients with metastatic melanoma. There were complete responses in 78% of the tumors and 17% partial responses. Although ECT was not a cure for melanoma, it was shown to be an effective alternative to palliative surgery or radiation (Glass et al., 1996b). That same year, a phase I/II clinical trial demonstrated ECT safety and efficacy for several cutaneous and subcutaneous tumors including melanoma, basal cell carcinoma, and metastatic adenocarcinoma. There were complete responses, decreases in tumor size, and objective responses showing that ECT was an effective treatment for most of the tumor nodules (Heller et al., 1996a).
Poly(Alkyl Cyanoacrylate) Nanoparticles for Delivery of Anti-Cancer Drugs
Published in Mansoor M. Amiji, Nanotechnology for Cancer Therapy, 2006
R. S. R. Murthy, L. Harivardhan Reddy
The antitumor efficacy of a medical-grade cyanoacrylate adhesive MK-8-based composition with prospidin has been studied by Chissov et al.,134 and the kinetics of the drug elimination have been followed up in a rat model. The findings showed a prolongation of the relapse-free period and a longer survival of the experimental animals. Clinical trials of the composition carried out in 70 patients with esophageal carcinomas showed local disseminated forms in 52 patients. Application of the adhesive composition has not increased the rate of postoperative complications; in some cases, the life span of patients after palliative surgery was considerably longer. In a study by Pérez et al.135 using an N-butyl-2-cyano acrylate-based tissue adhesive, Tisuacryl, as a nonsuture method for closing wounds in oral surgery involving apicectomy, molar extractions, and mucogingival grafting, the adhesive was well tolerated by the tissue and permitted immediate hemostasis and normal healing of incisions.
A Study of Polyhydroxyalkanoates as Materials for Designing Fully Resorbable Biliary Stents
Published in Tatiana G. Volova, Yuri S. Vinnik, Ekaterina I. Shishatskaya, Nadejda M. Markelova, Gennady E. Zaikov, Natural-Based Polymers for Biomedical Applications, 2017
Tatiana G. Volova, Yuri S. Vinnik, Ekaterina I. Shishatskaya, Nadejda M. Markelova, Gennady E. Zaikov
The death rate in the reference group was 33.3% (2 out of 6 patients died). The main causes of death were complications of the underlying illnesses: the hepatorenal syndrome decompensated in one patient, and the other patient died from progressive multiple organ failure. None of the patients died in the treatment group. In the patients with the predictably unfavorable outcomes (with the cancer), the proposed approach reduced bilirubinemia without palliative surgery (biliodigestive anastomosis), minimized the surgical trauma, and did not cause rapid decompensation, which favorably influenced the treatment outcomes. The average time of the hospital stay in the reference group was 33.2±2.6 days, and in the treatment group – 30.7±1.8 days (Table 8.19).
Colonic stents for malignant bowel obstruction: current status and future prospects
Published in Expert Review of Medical Devices, 2019
Vittorio Maria Ormando, Rossella Palma, Alessandro Fugazza, Alessandro Repici
Indeed, surgery in patients with late-stage extracolonic tumors causing MBO has high risk of morbidity and mortality. Several studies have shown that in patients with MBO secondary to advanced ovarian cancer, palliative surgery has a morbidity of 5% to 49% and mortality of 5% to 15% [49].