NMD – Knowledge and References

NMD

Explore chapters and articles related to this topic

AI and Immunology Considerations in Pandemics and SARS-CoV-2 COVID-19

Published in Louis J. Catania, AI for Immunology, 2021

One of the weapons in our cells’ is an RNA surveillance mechanism called nonsense-mediated mRNA decay (NMD) that protects us from further genetic mutations that could cause disease. With the progression of new viral strains, mRNA can be easily genetically reprogrammed to recognize mutant viral strains and allows for the development of second generation vaccines that directly target processes critical to a virus’s life cycle.61

The clinical effectiveness of custom-contoured seating for wheelchair users with neuromuscular disorders: a scoping review

View Article

Journal Information

Published in Assistive Technology, 2023

Jonathan Hosking

Neuromuscular disorders (NMD) is a broad term describing a group of conditions which progressively impair the neuromuscular system as a result of injury to or dysfunction of the central and/or peripheral nervous system, neuromuscular junction, or skeletal muscle (Haliloglu, 2022; Michel & Collins, 2020). Individuals with NMD may experience musculoskeletal deformities, such as scoliosis or hip dysplasia, excessive movements due to poor motor control regulation or spasticity, and postural instability of the trunk from paralysis, weakness or hypertonicity (Ham et al., 1998). This can limit their ability to counteract the effects of gravity on posture during sitting. Consequently, wheelchair users with NMD may experience secondary complications including heightened risk of pressure injuries, compromise to gastrointestinal and respiratory function, pain, discomfort and functional limitations to activity and participation (Long, 2020; Turner, 2001).