Internal limiting membrane

The internal limiting membrane (ILM) is the innermost layer of the retina, which is a transparent structure composed of 10 layers. The ILM is one of the histological layers of the retina, which is responsible for separating the vitreous humor from the retina.From: Ophthalmological Imaging and Applications [2019], Annotated retinal optical coherence tomography images (AROI) database for joint retinal layer and fluid segmentation [2021]

Impact of Retinal Stimulation on Neuromodulation

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Published in Yu Chen, Babak Kateb, Neurophotonics and Brain Mapping, 2017

Deborah Zelinsky

The ganglion cell layer and the axons from the ganglion cells, termed the nerve fiber layer, are next in the progression of retinal layers toward the inside of the eyeball. Loss of nerve fiber layer tissue is found to be an early biomarker for neurodegenerative diseases, such as Alzheimer’s disease and glaucoma (Valenti 2011). The final layer is the porous internal limiting membrane separating the retina from the vitreous. From there, 1.2 million signals travel through the optic nerve further into the brain for processing (Figure 22.12).

Annotated retinal optical coherence tomography images (AROI) database for joint retinal layer and fluid segmentation

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Published in Automatika, 2021

Martina Melinščak, Marin Radmilović, Zoran Vatavuk, Sven Lončarić

To detect IRF, SRF, and PED, the knowledge of their location within or outside specific retinal layers can be used to facilitate their detection and differentiation. The retina is histologically divided into 10 layers: (1) internal limiting membrane (ILM), (2) retinal nerve fibre layer (RNFL), (3) ganglion cell layer (GCL), (4) inner plexiform layer (IPL), (5) inner nuclear layer (INL), (6) outer plexiform layer (OPL), (7) outer nuclear layer (ONL), (8) external or outer limiting membrane (ELM or OLM), (9) photoreceptor layer, and (10) retinal pigment epithelium/Bruch’s membrane complex (RPE/BM). The layers visible in the OCT scan have been correlated to these histological layers, with the exception of a few additional zones observed in the photoreceptor layer for which the exact histological counterpart is not yet defined [36].

Internal limiting membrane

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Impact of Retinal Stimulation on Neuromodulation

Annotated retinal optical coherence tomography images (AROI) database for joint retinal layer and fluid segmentation