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Point cloud characterization
Published in Rodrigo Rojas Moraleda, Nektarios A. Valous, Wei Xiong, Niels Halama, Computational Topology for Biomedical Image and Data Analysis, 2019
Rodrigo Rojas Moraleda, Nektarios A. Valous, Wei Xiong, Niels Halama
A dataset consisting of 360 SPDM images as point clouds is used for validation. Green and yellow fluorescent protein markers are used for labelling chromatin. Antibodies for the histones H3K4 and H4K20 are used to label euchromatin and heterochromatin, respectively. The results show that heterochromatic regions alone indicate a relaxation after radiation exposure and re-condensation during repair, while euchromatin seems to be unaffected or behaves in a contrary fashion (Fig. 5.1ii). This differentiation can be seen by the respective persistent diagrams (Fig. 5.1i).
Epigenotoxicity: a danger to the future life
Published in Journal of Environmental Science and Health, Part A, 2023
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Abnormal and excessive blood pressure in the pulmonary artery causes PHD, eventually leading to right ventricular dysfunction. In recent decades, the importance of epigenetic therapy mediated by DNA methylation alterations and histone modifications has been highlighted in treating lung disease. Using di-methyltransferase SUV4-20H1, knockout mouse caused a PHD phenotype that further confirm the role of histone methyltransferase in the etiology of this disease. The methyl-CpG-binding domain protein family, is a regulatory factor in DNA methylation that was shown to increase in expression in PHD patients’ pulmonary arteries, cigarette smoke (CS)-exposed rat models’ pulmonary arteries, and human pulmonary artery cells exposed to CS, indicating the role of epigenetic modulator in CS-induced PHD. Indeed, epigenetic factors play an essential role in the elevation of blood pressure in the pulmonary arteries (Table 2).[11] According to the previous research, there is a substantial decrease in histone modification of H4K20me2/3 in human patients with COPD, unlike patients with PHD that makes them responsive to epigenetic drug effect.[171] The methylation of H4K20me2/3 was attributed to the activity of the H4K20 di-methyltransferase SUV4-20H1. Smoking or exposure to environmental CS significantly alters gene methylation in COPD-related diseases, especially PHD. One of the regulatory factors of DNA methylation is the methyl-CpG-binding domain protein family (MBD). The MBD2 protein is a factor of the MBD protein family, which acts as a reader in DNA methylation. MBD2 can intervene in transcriptional repression or activation by merging methylated DNA or collecting proteins to form a suppressive combination.[172]