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Ocular Drug Delivery Systems
Published in Ambikanandan Misra, Aliasgar Shahiwala, In-Vitro and In-Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes, 2018
Shubhini A. Saraf, Jovita Kanoujia, Samipta Singh, Shailendra K. Saraf
Contact lenses are defined as thin and curved plastic disks which are intended to envelop the cornea. The contact lenses loaded with a drug are placed in to eye, where they adhere to the eye surface due to the existing surface tension. The polymers extensively used for fabrication of contact lenses are silicon hydrogel and poly(hydroxyethyl methacrylate). The benefits of using contact lenses are longer residence time, leading to elevated drug flux via the cornea, and less nasolacrimal drainage (Gupta and Aqil 2012). Recently, contact lenses loaded with particles have been investigated for improved loading and sustained release action. For this type of a delivery system, drugs are loaded in colloids such as liposomes, nanoparticles, and microemulsions. Further, these colloids are dispersed in the contact lenses.
Assessment of ocular surface response to tinted soft contact lenses with different characteristics and pigment location
Published in International Journal of Optomechatronics, 2020
Min-Yen Hsu, Pei-Yu Hong, Jyh-Cheng Liou, Yu-Ping Wang, Connie Chen
Many people who wear contact lenses for the first time may be unaware of the correct use and cleaning procedures if they did not receive or follow professional instructions from an ophthalmologist or optometrist. The incorrect use and cleaning of contact lenses can cause morbidities including corneal ulcers, limbal neovascularization, corneal abrasion, irritation, and even serious infections and inflammation.[16] Stapleton et al. suggested that there was an increased risk of microbial keratitis in wearers purchasing their contact lenses on the Internet.[17] In addition, Sauer and Bourcier reported that, in particular, the first incorrect use of soft contact lenses increased the risk of microbial keratitis.[12] Therefore, it is necessary to pay attention to the proper timing and cleaning procedures for wearing such lenses.
Localization of full-length recombinant human proteoglycan-4 in commercial contact lenses using confocal microscopy
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Steven Cheung, Lakshman N. Subbaraman, William Ngo, Gregory D. Jay, Tannin A. Schmidt, Lyndon Jones
Contact lenses are biomedical devices that are used to correct refractive errors to improve visual acuity. With the increasing trend in the prevalence of myopia [1], contact lenses have become one of the most commercially successful biomedical products, with over 140 million lens wearers worldwide [2]. Part of its success can be attributed to its continuing evolution of lens material chemistry to meet the needs of the wearer [3,4]. Some of these include lower modulus [5,6], greater oxygen permeability [6–8], and enhanced material wettability [9–11], to name a few.
Ofloxacin laden microemulsion contact lens to treat conjunctivitis
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Yanchun Li, Chao Huang, Xiaolan Yang, Xin Zhang
No symptoms of ocular irritations such as opacity of cornea, inflammation or swelling of the iris, conjunctivae redness, chemosis, and discharge were observed after instillation of the test extract at various time intervals. Redness and chemosis of conjunctivae of grade 1 was observed with the sesame oil test as well as control group, which reduced with time. The symptoms of ocular irritation were not observed at various time intervals as compared to the control group, thus the contact lens was safe for ocular application.