Functional Foods
Datta Sourya, Debasis Bagchi in Extreme and Rare Sports, 2019
Eleutherococcus senticosus (E. senticosus) is a woody shrub belonging to Araliaceae family, commonly called Siberian ginseng or Acanthopanax senticosus or ciwujia. E. Senticosus’ roots and stem (barks) have been used in traditional Chinese medicine (TCM) for curing various illness as it is a potent adaptogen (anti-stress). The roots of E. senticosus contain several major phytocomponents including sesamin, lignans, coumarin, β-sitosterol and syringaresinol, eleutherosides which contribute to various biological properties (Bai et al., 2011). It exhibits many pharmacological activities including anti-inflammatory, anti-oxidant and anti-microbial (Kimura and Sumiyoshi, 2004; Sumiyoshi and Kimura, 2016). E. senticosus has been suggested to improve cardiorespiratory fitness and endurance performance due to lipolytic and anti-fatigue activity (Goulet and Dionne, 2005; Zhang et al., 2010). Copious numbers of clinical and pre-clinical studies demonstrated that administration of E. senticosus increased VO2 max (exercise tolerance), glycogen contents, β-oxidation of FA (lipolysis) with decreased lactate (upregulating the expression of LDH), BUN and cortisol levels thereby improving athletic performance in different endurance sports (Huang et al., 2011; Kuo et al., 2010; Sumiyoshi and Kimura, 2016).
Anti-Obesity Potential of Indian Traditional Medicinal Plants and Their Phytochemicals
Parimelazhagan Thangaraj in Medicinal Plants, 2018
In one study, Kim and Kang (2005) showed the administration of an extract of Panax ginseng in humans for 8 weeks, which decreased circulating cholesterol, triglyceride and low-density lipoprotein levels (LDL). Each subject ingested 2 g of Panax ginseng extract three times a day. Lee et al. (2008) reported that healthy postmenopausal women treated for six months with Eleutherococcus senticosus supplementation showed significant decreases in serum LDL levels and LDL/HDL ratios. In other study, Sugiyama et al. (2007) assessed six healthy male volunteers that followed a high-fat diet with 40 g of fat with 10 control or 10 apple polyphenol (Malus domestica) capsules (600 or 1500 mg). In this study, they demonstrated that apple polyphenols may prevent obesity in humans by a pancreatic lipase inhibitory mechanism.
Herbs with Antidepressant Effects
Scott Mendelson in Herbal Treatment of Major Depression, 2019
There are limited human trials suggesting that Eleutherococcus senticosus can improve symptoms of depression. Subjects described as suffering “neurosis” had significantly improved sleep, well-being, appetite, stamina, cognitive function, and mood after four weeks of treatment with Eleutherococcus senticosus.17 In a randomized study of Eleutherococcus senticosus on quality of life in elderly patients over 65 years of age, improvements in social functioning, mental health, and cognitive function were observed after four weeks of therapy, but these differences did not persist to the eight-week time point.18
Natural products for the management of the hepatitis C virus: a biochemical review
Published in Archives of Physiology and Biochemistry, 2020
Walid Hamdy El-Tantawy, Abeer Temraz
A clinical trial was conducted by Sheir et al. (2013), the authors used safe natural products [Blue green® tablet (Rhodiola rosea L. root dry extract; Eleutherococcus senticosus Maxim. root dry extract; Ginkgo biloba L. leaf dry extract; Klamath microalgae, Aphanizomenon flos aquae (50 mg), tablet-original natural company, Italy; 2 tablet/30 kg once daily; vitamin D: 1000 IU/day; tablespoon filled with paste made of linolenic acid, black seeds powder and honey; and 250 mg chloroquine (chloroquine, the known antimalarial drug exerts direct antiviral effect inhibiting pH dependent steps of the replication of several viruses including members of the flavin viruses, retro viruses and corona viruses) once daily for 10 days and then every 3 days through the duration of therapy] in treatment of HCV patients with detectable HCV RNA with different stages of fibrosis and cirrhosis refusing or unfit for combined Interferon Ribavirin (INF/RBV) therapy or who failed to achieve sustained virological response (SVR) to INF/RBV from April 2009 to March 2012 were included in this study.
Influence of andrographolide on the pharmacokinetics of warfarin in rats
Published in Pharmaceutical Biology, 2018
Xiaoli Zhang, Xiaosu Zhang, Xiaocui Wang, Meijun Zhao
Some other research has also found that when andrographolide was co-administered with other drugs such as naproxen, nabumetone and glyburide, their bioavailability would be increased (Balap et al. 2016, 2017; Samala and Veeresham 2016). Hovhannisyan et al (Hovhannisyan et al. 2006) have also investigated the effects of Kan Jang extract (a standardized fixed combination of extracts from Andrographis paniculata and Eleutherococcus senticosus) on the pharmacokinetics of warfarin in rats, and the results indicated that Kan Jang extract could increase the Cmax of warfarin in rats, and however, the difference was not significant (p > 0.05). We infer that the concentration of andrographolide might be lower than that used in our study.
Herbal medicine for psychiatric disorders: Psychopharmacology and neuroscience-based nomenclature
Published in The World Journal of Biological Psychiatry, 2019
Siu W. Tang, Wayne H. Tang, Brian E. Leonard
Some herbs appear to possess neuroactive properties but have not been clearly shown to have a dominant specific neurotransmitter action. The term ‘adaptogens’ refers to these herbs (Panossian 2013; Levin 2015). Rhodiola rosea, Eleutherococcus senticosus, Schisandra chinensis and Panax ginseng are all within this category. They have been used for centuries for general health enhancement, such as the relief of chronic fatigue (Choi 2016), and also for some specific CNS disorders such as Alzheimer’s disease (Wang et al. 2016a).
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