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Medical Treatment of Vanishing Bile Duct Syndrome in Adults
Published in Gianfranco Alpini, Domenico Alvaro, Marco Marzioni, Gene LeSage, Nicholas LaRusso, The Pathophysiology of Biliary Epithelia, 2020
C. Squarcia Giussani, Andrea Crosignani, Mauro Podda
In patients with graft-versus-host disease, a significant improvement of biochemical indices of cholestasis and cytolysis during UDCA administration was observed. More recently, a controlled study showed that UDCA administration significantly reduces the incidence of veno-occlusive syndrome after allogenic bone transplantation.163
Engineering Bone Formation with Biologically Inspired Nanomaterials
Published in Iniewski Krzysztof, Integrated Microsystems, 2017
Clinical methods of treating skeletal defects [1] involve bone transplantation or the use of synthetic materials to restore continuity. Autograft tissue is limited by supply and morbidity at the harvest site. Allograft tissue is limited by disease transfer and immunogenic response from the host tissue. Stress shielding and particulate wear are potential concerns with the use of nondegradable polymers such as poly(methyl methacrylate), PMMA. Bioinspired synthetic composites are an attractive option because mechanical properties can be designed independently for each application. In addition, the composite degradation can be designed to coincide with the rate of tissue regeneration for a given application.
Vaginal Vault Prolapse: Sacrofixation
Published in Victor Gomel, Bruno van Herendael, Female Genital Prolapse and Urinary Incontinence, 2007
Jacques Donnez, Jean-Paul Squifflet, Pascale Jadoul, Mireille Smets
Postoperative discomfort was similar to that observed after any straightforward laparoscopy. Bowel function resumed within 24 hr and the patients were able to leave hospital on average on day 2 to 4 postoperatively. Sexual intercourse was allowed three weeks after surgery. Patients were reviewed every six months. The follow-up in this series is now longer than five years. Two patients experienced spondylodiscitis, nine months and fifteen days postoperatively. The first one underwent laparotomy with disc resection and bone transplantation. The second was treated by laparoscopy, during which the mesh and coils were removed.
Combined treatment using cross-leg free flap and the Masquelet technique: a report of two cases
Published in Case Reports in Plastic Surgery and Hand Surgery, 2022
Takeo Osaki, Yasuko Hasegawa, Ryosuke Tamura, Tomoaki Fukui, Keisuke Oe, Takahiro Niikura, Tadashi Nomura, Kazunobu Hashikawa, Hiroto Terashi
We report two cases of tibial osteomyelitis after injury with a soft tissue defect that required free tissue transplantation. The orthopedic surgeon debrided the infected sequestrum of the affected limb and performed cement placement. We evaluated the vasculature with CT angiography and applied this method in the absence of appropriate recipient vessels in the affected limb. In addition, the tissue blood circulation around the defect was examined using skin perfusion pressure or transcutaneous oxygen tension to see whether distant flaps were possible. Concurrent with the cement replacement, we transplanted the latissimus dorsi muscle flap with a flow-through type in the posterior tibial artery on the contralateral side. Both lower limbs were fixed using external fixation (Figure 1). After the operation, the delay was performed using a tourniquet on the femur of the healthy side or by clamping the flap pedicle once a week or more. At that time, we performed ICG angiography and near-infrared spectroscopy to confirm neovascularization from the affected limb to the flap (Figure 2). ICG angiography was mainly used to determine where blood circulation was poor in the flap. Near-infrared spectroscopy was applied to areas with poor blood circulation in the flap. Near-infrared spectroscopy was used to verify that the oxygen saturation of the flap did not decrease even when the flap pedicle was clamped, and the flap was then divided. Bone transplantation was performed in the subsequent weeks while awaiting the stabilization of the blood circulation of the flap after flap division.
Total hip arthroplasty, combined with a reinforcement ring and posterior column plating for acetabular fractures in elderly patients: good outcome in 34 patients
Published in Acta Orthopaedica, 2019
Tõnis Lont, Jyrki Nieminen, Aleksi Reito, Toni-Karri Pakarinen, Ilari Pajamäki, Antti Eskelinen, Minna K Laitinen
Acute THA was performed by experienced revision arthroplasty surgeons together with pelvic trauma surgeons. Patients were placed under spinal anesthesia, and a dose of preoperative antibiotic prophylaxis was infused 30 min prior to surgery. A Kocher–Langenbeck approach was used. The posterior column was supported by adding posterior column plating and a GAP II reinforcement ring (Stryker, Mahwah, NJ, USA). Various components were used in both the femur and acetabulum throughout the study period, depending on the implant selected by the hospital (Table 1). In all acute THA cases, morselized autograft bone transplantation from the resected femoral head was performed using an impaction grafting technique (Hosny et al. 2017). In the first acute THA case, anterior column reduction and fixation was performed using an AIP approach. Additional anterior fixation was not applied in any subsequent patients.
Osteogenic differentiation of Wharton’s jelly-derived mesenchymal stem cells cultured on WJ-scaffold through conventional signalling mechanism
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Bahareh Beiki, Bahman Zeynali, Ehsan Taghiabadi, Ehsan Seyedjafari, Mousa Kehtari
The development of tissue engineering has made it an attractive method with great repairing potential for tissue defects. Bone tissue engineering techniques based on autogenously cell/tissue transplantation would eliminate problems of donor compatibility, limitation of autograft implantation, pathogen transfer and immune response of allograft bone transplantation [1]. The bone tissue engineering requires cellular components, scaffolds and growth factors. The scaffold provides the initial extracellular matrix (ECM) required to support the cells adhesion, proliferation and differentiation [2]. Currently, the scientific challenges of bone tissue engineering are to develop suitable three-dimensional (3D) biodegradable and biocompatible scaffolds that easily are fabricated into a variety of shapes and sizes with desirable mechanical properties and interconnecting porosity [3,4].