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Congenital Central Hypoventilation Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Expressed during neural development in the nuclei of brainstem areas that contain pathways controlling breathing and auditory functions [5], PHOX2B is regulated transcriptionally by itself, as well as E2a and Hand2 at specific sympathetic and enteric nervous system developmental stages. Other proteins that may play a possible role in the regulation of PHOX2B are SOX10, PHOX2A, and HASH1. Further, by forming trimer with Pbx1 and Meis1, Hoxb1 and Hoxb2 also contribute to the regulation of PHOX2B transcription.
Survival Outcome and Clinicopathologicl analysis of Homeobox gene cluster-embedded LncRNAs in Human Cancers: A Systematic Review and Meta-analysis
Published in Expert Review of Molecular Diagnostics, 2021
Min Gao, Zhigang Cui, Sixuan Li, Na Li, Lianwei Tong, Ying Wang, Mingyang Song, Baosen Zhou, Zhihua Yin
HOXB-AS1 and HOXB-AS3 were the mainly HOX-related LncRNAs located in HOXB clusters, which of them have been reported to be aberrant regulation in various cancers, like colon cancer, ovarian cancer, and lung cancer [44–46]. According to the previous studies, HOXB-AS1 was ectopic up-regulation in tumor tissues than adjacent normal tissues and exacerbated poor survival outcome among different cancers. HOXB-AS1 could promote the cell growth, migration, and regulate the expression of tumor-related genes like HOXB2 and Wnt10b by directly binding to miR-885-3p and miR-149-3p [47,48]. Another LncRNA HOXB-AS3 has been described to be positively correlated with the poor survival time among ovarian cancer, acute myeloid leukemia, and associated a better prognosis in colon cancer [44,49,50]. In addition to being a transcription factor regulating the occurrence and development of tumors, the loss of HOXB-AS3 peptide could also antagonize the hnRNP A1-mediated regulation of pyruvate kinase M splicing by restraining the binding of the ariginine residues in RGG motif of hnRNP A1, which played as an oncogenic role in colon metabolic reprograming [44].
Identification of KLRC2 as a candidate marker for brain tumor-initiating cells
Published in Neurological Research, 2019
Eriko Ishihara, Satoshi Takahashi, Raita Fukaya, Shigeki Ohta, Kazunari Yoshida, Masahiro Toda
From the results of the cDNA microarray, we selected the top 10 genes whose expressions in BTICs were higher, compared to expressions of NSC or glioma cells (summarized in Table 1). Then, we used these 20 genes to examine the EST database and find genes that expressed at least two-times higher in gliomas compared with normal brain tissue (Figure 1). Five genes, KLRC2 (GenBank Accession NO. NP_002251.2), KLRC1 (NP_002250.1), HOXB2 (NP_002136.1), KCNJ2 (NP_000882.1), and COL20A1 (NP_065933.2) were identified. The cDNA microarray revealed that five of these genes, KLRC2, KLRC1, HOXB2, and KCNJ2 were expressed more than 200 times higher in BTICs compared to NSC. COL20A1 was expressed more than 50 times higher in BTICs than glioma cell lines (Table 1).