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Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
Plantago ovata is very beneficial for the patients suffering from hemorrhoids by reducing the bleeding, improving the symptoms, and reducing the hemorrhoidal cushions. This bulking laxative is a stool softener that has therapeutic use for posthemorrhoidectomy complications. P. ovata contains a large amount of short-chain fatty acids as well as soluble nonstarch polysaccharides. These polysaccharides, under anaerobic fermentation, produce propionate, butyrate, and acetate components in the intestines which play a critical role in reducing the inflammation of the anorectal region.
Nutraceutical Herbs and Insulin Resistance
Published in Robert E.C. Wildman, Richard S. Bruno, Handbook of Nutraceuticals and Functional Foods, 2019
Giuseppe Derosa, Pamela Maffioli
Plantago ovata, also known as Plantago psyllium or psyllium, belongs to the category of gel-forming fibers and acts positively against constipation as well as with a mass action, even at the metabolic level: Influencing, that is, the transformation and use of nutrients to varying degrees. The fibers, in fact, are fermented in the colon, producing healthy bacteria and short chain fatty acids (SCFAs), which in turn improve the flora and reactivate intestinal peristalsis, improving in this way all intestinal functions and thus counteracting more complete constipation, preventing relapses, especially if appropriate and well-planned therapies are performed. Furthermore, the gel of the gel-forming fibers softens feces and facilitates their expulsion. Even in subjects suffering from hemorrhoids, therefore, the combined actions performed by the gel-forming fibers are able to provide a better therapeutic and prophylactic action than insoluble fibers, which give almost exclusively mass action, provided that the subject takes on large quantities of water. Several studies have been published in the literature on the positive effects of psyllium; for example, Derosa et al. published a 6-month study where 141 overweight and hypertensive subjects were randomized to take psyllium or guar gum 3.5 g three times a day 20 minutes before main meals or standard diet. Both fibers significantly improved body mass index (BMI), glycemia and FPI, HOMA-IR, HbA1c, LDL cholesterol, and Apo B levels, but only psyllium led to significant improvement of the Tg and pressure values.67,68 Furthermore, a meta-analysis published in 2012 showed that supplementation with psyllium led to a significant improvement in the frequency of defecation compared to placebo (OR = 1.19; 95% CI: 0.58–1.80, p < 0.05). The number of discharges per week increased in the psyllium-treated group compared to placebo (OR = 1.19; 95% CI: 0.58–1.80, p < 0.05).69
Induced mutation breeding for qualitative and quantitative traits and varietal development in medicinal and aromatic crops at CSIR-CIMAP, Lucknow (India): past and recent accomplishment
Published in International Journal of Radiation Biology, 2020
Raj K. Lal, Chandan S. Chanotiya, Pankhuri Gupta
A number of mutation studies were conducted through gamma radiation over time in 12 medicinal and aromatic plants, viz. black henbane (Hyoscyamus niger L.), opium poppy (Papaver somniferum L.) and psyllium/isabgol (Plantago ovata F.), CIM Ajar, CIM Nirom, and CIM Sfurti in the Kewanch (Mucuna pruriens (L.) DC.), pyrethrum (Chrysanthemum cinerariifolium), and Roselle (Hibiscus Sabdariffa L.) among medicinal plants, and German chamommile (Chamomilla recutita [L.] Rauschert), rose-scented geranium (Pelargonium graveolens L'Hér. ex Aiton), Muskdana (Abelmoschus moschatus), palmarosa (Cymbopogon martini var. Motia (Roxb. Wats.), and Java citronella (Cymbopogon winterianus Jowitt), Ceylon citronella (Cymbopogon nardus var. nadus), Vetiver (Chrysopogon zizanioides (L.) Roberty), and lemongrass (Cymbopogon flexuosus Steud. Wats) among aromatic plants at CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow − 226 015, India. No breeding method can rectify some inherent defects in different medicinal and aromatic crops (MACs) so rapidly as mutation breeding could do as done by several research workers in the MACs (Sharma and Singh 1983; Lavania et al. 1985; Annual Reports 1986; Sharma et al. 1986; Misra and Sharma 1990; Misra et al. 1991; Sharma et al. 1992; Lal et al. 1993; Micke 1995; Sharma et al. 1997a, 1997b; Lal et al. 1998b, Lal, Sharma, Misra, 1999; Sharma, Lal, Gupta, et al. 1999; Sharma, Lal, Misra, et al. 1999; Misra et al. 2001).
Induced polygenic variations through
Published in International Journal of Radiation Biology, 2019
Raj Kishori Lal, Chandan Singh Chanotiya, Ved Ram Singh, Sunita Singh Dhawan, Pankhuri Gupta, Shama Shukla, Anand Mishra
Chamomile belongs to the Asteraceae family. It is commercially an important and natural source of essential oil that contained terpenoids, fatty acid derivatives, etc. The oil is used in different perfumery and pharmaceutical preparations on a large scale. There is a huge demand of chamomile flowers as it is used in bathing and herbal tea (Sharma et al. 1983; Sharma et al. 1989). However, it was introduced in India about three centuries ago, chamomile could not be used enough under producing crops, because of its low essential oil content with poor flowers yield and also due to unpredictable market demand. The chamomile plant material had been investigated earlier and was determined to produce high flower yield and essential oil content, and isolated mutant was released as variety Vallary with dark blue oil by CSIR-CIMAP, Lucknow (Anonymous 1992). Previously, a number of research workers reported mutation breeding using γ-irradiation to obtain valuable mutants released as varieties for commercial cultivation in medicinal crops like Hyoscymus niger L mutant varieties Aekla and Yela (Sharma et al. 1989); Plantago ovata F mutant varieties Niharika and Mayuri (Lal et al. 1998; Sarkar and Lal 2018); Mucuna prurience varieties CIM Nirom and Sfurti (Lal et al. 2015; Singh et al. 2017). Aromatic grasses Cymbopogon winterianus variety Manjari and CIM-Jeeva (Lal et al. 1998).
Psyllium seed husk regulates the gut microbiota and improves mucosal barrier injury in the colon to attenuate renal injury in 5/6 nephrectomy rats
Published in Renal Failure, 2023
Dongmei Hu, Wenbo Liu, Wanlin Yu, Lihua Huang, Chunlan Ji, Xusheng Liu, Zhaoyu Lu
Psyllium seed husk (PSH) is a water-soluble, gelatinous mucilage extracted from Plantago ovata (blond plantain) [11]. PSH supplementation can effectively reduce the risk of cardiovascular diseases [12], improve blood lipid profiles, and regulate gut microbiota [13]. In a recent trial, plantain supplementation reduced the inflammatory response to colitis in mice. While this response was found to be largely dependent on the microbiome [14], the effects of PSH on the microbial ecosystem of CKD have not yet been investigated in detail. Therefore, in this study, the effects of PSH, as a representative dietary fiber, on the gut–kidney axis were examined in a well-described 5/6 nephrectomy (5/6Nx) rat model of CKD.